尖锐湿疣患者人乳头状瘤病毒感染类型与临床复发的相关性研究

发布时间：2018-03-07 07:31

本文选题：尖锐湿疣　切入点：人乳头状瘤病毒　出处：《中华医院感染学杂志》2014年07期 　论文类型：期刊论文

【摘要】：目的探讨尖锐湿疣(CA)患者人乳头状瘤病毒(HPV)感染类型与临床复发的相关性,为降低临床复发提供相关依据。方法回顾性分析2008年1月-2012年12月门诊及住院的106例CA患者,对其采用电灼术联合免疫疗法辅助治疗,并采用导流杂交基因芯片分型技术对疣体进行HPV的基因分型测定;随访患者3个月,记录不同感染类型的复发情况,采用SAS 8.0软件进行统计分析,计数资料比较采用χ2检验。结果 106例CA患者中HPV-DNA的阳性率为92.5%;共检测出5种HPV基因类型,其中单一型感染72例,均为低危型HPV6占37.76%、HPV11占35.71%,复合型感染26例,以低危型HPV6+11为主,占16.33%;单一型感染、低危型感染的复发率均显著低于复合型感染、高危型感染,差异均有统计学意义(P0.05)。结论 CA患者以HPV6、11型感染为主,且HPV感染类型与CA的临床复发具有一定的相关性。
[Abstract]:Objective to investigate the correlation between the types of HPV infection and clinical recurrence in patients with condyloma acuminatum. Methods 106 patients with CA from January 2008 to December 2012 were retrospectively analyzed. The HPV genotyping of warts was determined by electrocautery combined with immunotherapy, and the recurrence of different types of infection was recorded after 3 months follow-up. Results the positive rate of HPV-DNA in 106 patients with CA was 92.5%, and 5 types of HPV gene were detected, among which 72 cases were single type infection. Low risk type HPV6 accounted for 37.76%, HPV11 accounted for 35.71%, compound type infection was 26 cases, low risk type HPV6 11 was the main type, accounting for 16.33.The recurrence rate of single type infection and low risk type infection was significantly lower than that of complex type infection, high risk type infection, and high risk type infection, the recurrence rate of single type infection and low risk type infection was significantly lower than that of complex type infection, high risk type infection. Conclusion HPV6M11 infection is the main type of CA, and the type of HPV infection is correlated with the clinical recurrence of CA.
【作者单位】：杭州市萧山区皮肤病医院皮肤科;
【基金】：浙江医药卫生一般研究计划基金项目(2011KYB155)
【分类号】：R752.53

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