5-氨基酮戊酸光动力疗法治疗宫颈内膜外移伴HPV亚临床感染的临床观察

发布时间：2018-03-11 01:39

本文选题：-氨基酮戊酸　切入点：光动力　出处：《中国皮肤性病学杂志》2014年09期 　论文类型：期刊论文

【摘要】：目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗宫颈内膜外移伴人类乳头瘤病毒(HPV)亚临床感染的疗效。方法将68例宫颈内膜外移伴HPV亚临床感染患者随机分为两组,每组34例。治疗组完成1疗程的ALA-PDT治疗,共3次,每次间隔7~10d;对照组采用传统的微波治疗1次;随访3个月后判断临床疗效,1年后比较HPV转阴率。结果治疗组34例经1疗程治疗后完全缓解率为73.53%(25/34);部分缓解率为26.47%(9/34)。对照组34例完全缓解率为88.24%(30/34);部分缓解率为11.76%(4/34)。治疗组34例仅有轻度腹部坠胀及阴道分泌物稍增多,未出现阴道出血及宫颈疤痕。微波对照组34例均出现阴道排液、出血,4例宫颈疤痕。随访1年后治疗组HPV转阴率88.24%;对照组HPV转阴率32.35%。ALA-PDT与传统的微波治疗相比,完全缓解率差异无统计学意义(P=0.12);HPV转阴率差异有统计学意义(P0.01)。结论 ALA-PDT治疗宫颈内膜外移伴HPV亚临床感染,副作用少,疗效可靠。
[Abstract]:Objective to investigate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of subclinical infection of cervical endometrium with human papillomavirus (HPV). Methods Sixty-eight patients with HPV subclinical infection were randomly divided into two groups. 34 cases in each group. The treatment group completed a course of ALA-PDT treatment for 3 times, every time at intervals of 7: 10 days, while the control group was treated with traditional microwave therapy once; Results after one course of treatment, the complete remission rate of 34 cases in the treatment group was 73.53 / 34 / 34, the partial remission rate was 26.47% / 34 / 34, the complete remission rate in the control group was 88.24% 30 / 34% and the partial remission rate was 11.76 4 / 34%. In the treatment group, 34 cases had only slight abdominal bloating and a slight increase in vaginal secretion. There was no vaginal bleeding or cervical scar. Vaginal effusion was found in 34 cases and cervix scar in 4 cases in microwave control group. After one year follow-up, the negative rate of HPV in treatment group was 88.240.The negative rate of HPV in control group was 32.35%. ALA-PDT was compared with traditional microwave therapy. There was no significant difference in complete remission rate (P < 0.01). Conclusion ALA-PDT has less side effect and reliable curative effect in the treatment of cervical endometrium with subclinical infection of HPV.
【作者单位】：佛山市妇幼保健院;广州医科大学附属第三医院;
【基金】：佛山市卫生局科研项目(2013160) 广东省自然科学基金项目(S2012040006869) 广东省医学科研基金项目(广东省卫生厅A2012273) 广州市科技计划项目(穗科信字[2013]166号,2013J4100102)
【分类号】：R752.53

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