红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

发布时间：2018-03-14 16:42

  本文选题：红蓝光　切入点：西黄胶囊　出处：《吉林大学学报(医学版)》2016年04期 　论文类型：期刊论文

【摘要】：目的:采用红蓝光照射联合西黄胶囊治疗面部中重度痤疮,并评价其疗效及安全性。方法:80例中重度痤疮患者随机分为西黄胶囊组(对照组)和红蓝光照射联合西黄胶囊组(观察组),每组40例。对照组患者口服西黄胶囊,每次1.5g,每日2次;观察组患者采用红蓝光照射治疗,每次20min,每周2次,同时口服西黄胶囊,每次1.5g,每日2次;治疗时间均为4周。治疗后2和4周各随访1次,观察患者皮损变化情况及不良反应发生情况,比较其疗效。结果:治疗2周后,观察组总有效率为67.5%,对照组为52.5%,2组总有效率比较差异无统计学意义(P0.05),但观察组患者炎性皮损和非炎性皮损消退数目明显多于对照组(P=0.002和P=0.005);治疗4周后,观察组总有效率为85.0%,对照组总有效率为65.0%,观察组疗效明显优于对照组(P0.05),且观察组患者炎性皮损和非炎性皮损消退数目均明显多于对照组(P=0.01和P=0.001)。治疗期间2组患者均未见严重不良反应,观察组仅有2例患者在红光照射治疗后有轻度头痛及恶心症状,下调照射剂量后症状消失。结论:红蓝光照射联合西黄胶囊治疗面部中重度痤疮具有见效快、疗效好、安全性高的优势,值得在临床上推广应用。
[Abstract]:Objective: to treat facial moderate and severe acne with red and blue light irradiation combined with Xihuang capsule. Methods 80 patients with moderate and severe acne were randomly divided into Xihuang capsule group (control group) and red and blue light irradiation combined with Xihuang capsule group (40 cases in each group). The patients in the observation group were treated with red and blue light irradiation for 20 minutes, twice a week, and Xihuang capsule twice a day for 1.5 g each time. The treatment time was 4 weeks, followed up 2 and 4 weeks after the treatment, and the patients in the observation group were treated with red and blue light irradiation twice a day, and the patients in the observation group were followed up for 2 and 4 weeks. The changes of skin lesions and the occurrence of adverse reactions were observed, and the curative effects were compared. Results: after 2 weeks of treatment, The total effective rate of the observation group was 67.5 and that of the control group was 52.5. There was no significant difference in the total effective rate between the two groups. However, the number of inflammatory lesions and non-inflammatory lesions in the observation group was significantly higher than that in the control group (P 0.002 and P 0.005), and after 4 weeks of treatment, the number of inflammatory lesions and non-inflammatory lesions in the observation group was significantly higher than that in the control group. The total effective rate of the observation group was 85.0 and the total effective rate of the control group was 65.0. The curative effect of the observation group was significantly better than that of the control group (P 0.05), and the number of inflammatory skin lesions and non-inflammatory skin lesions in the observation group was significantly higher than that in the control group. No serious adverse reactions were observed, In the observation group, only 2 patients had mild headache and nausea after red light irradiation, but the symptoms disappeared after lowering the dose of irradiation. Conclusion: red and blue light irradiation combined with Xihuang capsule is effective and effective in the treatment of moderate and severe acne on the face. The advantage of high safety is worth popularizing in clinic.
【作者单位】： 吉林大学中日联谊医院皮肤科;吉林大学中日联谊医院病理科;
【基金】：吉林省科技厅社会发展处基金资助课题(20090471)
【分类号】：R758.733
，

本文编号：1612060