寻常型银屑病患者IL-22水平的变化及其临床意义

发布时间：2018-03-17 13:50

本文选题：白细胞介素　切入点：酶联免疫吸附法　出处：《重庆医学》2014年21期 　论文类型：期刊论文

【摘要】：目的探讨寻常型银屑病患者血清IL-22水平与银屑病面积和严重程度指数(PASI)及治疗转归的关系。方法应用ELISA检测39例寻常型银屑病患者及51例正常对照的血清IL-22水平,比较两组血清IL-22水平的差异,评估银屑病患者IL-22水平与PASI之间的关系并对比治疗前后的变化。结果病例组治疗前血清IL-22的水平较对照组高(t′=8.578,P0.01),且与PASI呈正相关(r=0.64,P0.05)。治疗4周及8周后血清IL-22均较治疗前下降(q=6.994,P0.05;q=9.501,P0.05),PASI变化也表现了同样的趋势(q=36.27,48.26,P0.05)。结论 IL-22在寻常型银屑病的发病中可能起重要作用,其血清水平可作为疾病严重程度以及疗效评估的指标之一。
[Abstract]:Objective to investigate the relationship between serum IL-22 level, psoriasis area and severity index (PASI) and outcome of treatment in patients with psoriasis vulgaris. Methods Serum IL-22 levels were measured by ELISA in 39 patients with psoriasis vulgaris and 51 normal controls. To compare the difference of serum IL-22 level between the two groups, The relationship between IL-22 level and PASI in psoriatic patients was evaluated and the changes before and after treatment were compared. Results the serum IL-22 levels in the patients with psoriasis before treatment were higher than those in the control group (8.578P 0.01g), and there was a positive correlation with PASI. The serum IL-22 levels were higher after 4 weeks and 8 weeks of treatment than those in the control group. Before treatment, the changes of PASI of P0.05P0.05P0.05P0.05P0.05 / 9.501P0.05PASI also showed the same trend before treatment. Conclusion IL-22 may play an important role in the pathogenesis of psoriasis vulgaris, and the change of PASI is similar to that of PASI of P0.05P0.05. Conclusion IL-22 may play an important role in the pathogenesis of psoriasis vulgaris. Its serum level can be used as one of the indicators of disease severity and curative effect evaluation.
【作者单位】：海南省农垦总医院皮肤科;广东省惠州市皮肤病医院皮肤科;海南省农垦总医院体检中心;
【分类号】：R758.63

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