232例晚期黏膜黑色素瘤患者的一二线治疗疗效及预后影响因素

发布时间：2018-03-21 15:01

本文选题：黏膜黑色素瘤　切入点：CKIT突变　出处：《中国肿瘤生物治疗杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的:探讨晚期黏膜黑色素瘤(mucosal melanoma,MM)患者的临床特征、治疗及预后影响因素。方法:收集2008年1月至2015年12月北京肿瘤医院肾癌黑色素瘤内科收治的232例晚期MM患者的临床资料,一二线治疗方案,对患者生存情况进行随访,并对影响总生存期的多因素预后进行分析统计。结果:本组晚期MM患者共232例(男101、女131例),中位年龄56.0岁;原发部位:直肠肛管29.3%,鼻腔25.0%,泌尿生殖道20.7%,口腔20.3%,食管4.7%;就诊时M分期:M1a 17.2%,M1b 21.6%,M1c 61.2%;多数患者存在多处转移,常见转移部位为肺50.4%、肝34.9%、骨23.3%。中位PFS:一线治疗方案患者4.5个月,二线治疗方案患者2.5个月。所有患者中位OS为11.0个月,其中M1a期16.0个月、M1b期14.0个月、M1c期10.0个月。预后分析发现,就诊时M分期和血清LDH与OS显著相关(P0.01),与原发灶部位、性别、年龄、基因突变状态等无显著相关性。结论:鼻腔、口腔是MM的好发部位,就诊时M分期、LDH水平是OS的独立预后因素。
[Abstract]:Objective: to investigate the clinical features, treatment and prognostic factors of patients with advanced mucosal melanoma (MMM). Methods: from January 2008 to December 2015, 232 patients with advanced MM in the Department of Renal carcinoma melanoma, Beijing tumor Hospital, were collected. Results: 232 patients with advanced MM (male 101, female 131, median age 56. 0 years old) were followed up with the first and second line therapy. Primary position: rectal and anal canal 29.3s, nasal cavity 25.0, genitourinary tract 20.7am, oral cavity 20.3cm, esophagus 4.7.The M stage: M1a 17.2and M1b 21.6C61.2; most patients have multiple metastases, the common metastatic sites are lung 50.4, liver 34.9, bone 23.33.PFS5 months. The median OS of all patients was 11.0 months, of which M1a stage was 16.0 months and M1b stage 14.0 months and M1c stage 10.0 months.Prognostic analysis showed that M stage and serum LDH were significantly correlated with OS at the time of treatment (P 0.01), and with primary site and sex. Conclusion: nasal cavity and oral cavity are the predilection sites of MM. The level of LDH in M staging is an independent prognostic factor of OS.
【作者单位】：北京大学肿瘤医院暨北京市肿瘤防治研究所肾癌黑色素瘤内科;北京大学肿瘤医院暨北京市肿瘤防治研究所国家药物临床试验机构恶性肿瘤发病机制及转化研究教育部重点实验室;
【基金】：国家自然科学基金(No.81603038) 北京市优秀人才青年骨干项目(No.2016000021469G186) 北京市医院管理局培育计划(No.PX2017042)~~
【分类号】：R739.5

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