特应性斑贴试验方法学的英文文献分析

发布时间：2018-03-22 06:03

本文选题：斑贴试验　切入点：特应性　出处：《临床皮肤科杂志》2014年07期 　论文类型：期刊论文

【摘要】：目的:分析特应性斑贴试验(atopic patch test,APT)应用现状,强调其临床价值。方法:整理有关APT方法学的英文文献114篇,对疾病种类、变应原、阳性率、灵敏度、特异度、阳性预测值、阴性预测值、受试部位、斑试器选择、封闭时间、判读时间、判读标准和试验前皮肤处理情况进行统计。结果:APT主要用于特应性皮炎(atopic dermatitis,AD)的诊断,所有统计文献涉及APT诊断AD的共84篇,占统计文献的73.7%;APT食物变应原中牛奶、鸡蛋、小麦、大豆最常见,涉及的文献分别占统计文献的45.6%,38.6%,29.8%和20.2%。各种变应原对应的特异度、阳性预测值及阴性预测值均较高,而阳性率、灵敏度、变异度较大。多数文献选择背部作为受试部位,变应原置于12mm芬兰小室,敷贴48 h,根据欧洲特应性皮炎工作小组(ETFAD)标准判读。结论:APT、在食入及吸入性过敏原相关疾病的诊断中具有较高的临床价值,但目前应用比较混乱,仍需不断实践推广其应用价值。
[Abstract]:Objective: to analyze the current application of atropic patch test (APT) and to emphasize its clinical value. Methods: 114 articles about APT methodology were collected, and the disease types, allergens, positive rate, sensitivity, specificity, positive predictive value were analyzed. Negative predictive value, site of test, spot tester selection, blocking time, interpretation time, interpretation criteria and skin treatment before the test were statistically analyzed. Results: apt was mainly used in the diagnosis of atopic dermatitis (AD). All the statistical documents involved 84 articles of APT diagnosis of AD, accounting for 73.7% of the statistical literature. Milk, eggs, wheat and soybeans were the most common allergens in the statistical literature. The positive predictive value and negative predictive value were higher, but the positive rate, sensitivity and variability were higher. Most literatures chose the back as the site of the test, and the allergen was placed in the Finnish chamber of 12mm. Application for 48 hours, according to the European working Group on atopic Dermatitis (ETFAD) standard. Conclusion: APT has a high clinical value in the diagnosis of ingestion and inhalation-related allergen diseases, but the current application is rather confused. It still needs to continue to practice and popularize its application value.
【作者单位】：徐州医学院附属医院皮肤科;上海市皮肤病医院皮肤与化妆品研究室;安徽医科大学上海皮肤病临床学院;
【分类号】：R758.2

【共引文献】