乳房外Paget病16例临床病理分析

发布时间：2018-03-22 14:42

本文选题：Paget病　切入点：乳房外　出处：《临床与实验病理学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨乳房外Paget病的临床及组织病理学特点。方法收集16例乳房外Paget病患者临床及组织病理学资料,并复习相关文献。结果本组男性15例,女性1例,平均年龄70.4岁。皮损主要发生于顶泌汗腺分布较丰富的区域,如阴囊、阴茎、肛周、会阴等部位,少数发生于腋窝、腹股沟。临床主要表现为境界清楚的浸润性红斑或斑块,表面渗出、糜烂和结痂。典型的组织病理特点为表皮内散在或成巢状分布的Paget细胞,免疫表型:CK7、CEA、GCDFP-15等均阳性,CK5/6、CK20、S-100蛋白、HMB-45等均阴性。结论乳房外Paget病是一种少见的恶性程度较低的肿瘤,好发于老年男性,该病误诊率高,早期临床易误诊为湿疹等疾病。典型的组织病理学表现结合免疫表型可明确诊断,对于疑似病例应及早行组织病理学检查有利于减少临床误诊,手术切除为首选治疗方法,若切除不完整极易复发,需长期随访。
[Abstract]:Objective to investigate the clinical and histopathological features of extramammary Paget's disease. Methods the clinical and histopathological data of 16 patients with extramammary Paget's disease were collected and the relevant literatures were reviewed. The average age was 70.4 years. The skin lesions mainly occurred in areas with abundant distribution of sweat glands, such as scrotum, penis, perianal, perineum and so on, and a few occurred in armpit and groin. The clinical manifestations were infiltrating erythema or plaque with clear boundary. Surface exudation, erosion and scab. Typical histopathological features are scattered or nestled Paget cells in the epidermis. The immunophenotype of CK7, CEA, GCDFP-15, et al were all negative. Conclusion extramammary Paget's disease is a rare tumor with low malignancy, and is prone to occur in elderly men, and the misdiagnosis rate of the disease is high. The typical histopathological manifestations combined with immunophenotype can be clearly diagnosed. Early histopathological examination should be used to reduce clinical misdiagnosis and surgical resection is the first treatment method. If excision is incomplete and easy to relapse, long-term follow-up is needed.
【作者单位】：江苏省泰州市姜堰区皮肤病防治所病理科;江苏省泰州市姜堰区皮肤病防治所皮肤科;
【分类号】：R739.5

【相似文献】