银屑病患者肠粘膜通透性及病情与饮食相关性的研究

发布时间：2018-03-24 21:44

本文选题：银屑病　切入点：肠粘膜通透性　出处：《兰州大学》2010年硕士论文

【摘要】： 第一部分进行期银屑病患者肠粘膜通透性变化的研究目的：研究银屑病患者肠粘膜通透性的变化,探讨银屑病的发病机制。方法：进行期寻常型银屑病患者40例,口服测试液50ml(含乳果糖10g、甘露醇5g),留取6h内全部尿液,用高效液相色谱法测定尿中乳果糖(L)与甘露醇(M)浓度,计算二者的比值(L／M),同时测定患者皮损基本消退后的L/M值。以20例健康成人作为对照。结果：银屑病患者组L／M比值为0.070±0.026,显著高于正常对照组(0.029±0.006)及同组患者治愈后(0.036±0.009)(P0.05)。结论：进行期寻常型银屑病患者肠粘膜通透性较正常人及皮损消退后患者增高,可能与银屑病的发生及发展有关。第二部分银屑病患者病情与饮食相关性的研究目的：探讨影响银屑病病情的饮食因素及其他相关因素。方法：采用问卷调查表,应用1：l配比病例对照研究,共调查200例寻常型银屑病患者的饮食及其他病情相关因素。使用单因素logistic回归分析结合多因素条件logist ic回归模型分析。结果：面粉(OR=2.214)、牛肉(OR=3.308)、羊肉(OR=2.145)、鱼虾(OR=1.952)、辣椒(OR=2.559)、洋葱(OR=1.519)、吸烟(OR=2.515)、饮酒(OR=2.205)、肥胖(OR=1.557)、咸菜酸菜(OR=1.752)是银屑病发病的可能危险因素。经常食用大米(OR=0.422)、粗粮(OR=0.252)、蛋类(OR=0.459)、鲜奶(OR=0.576)、苹果(OR=0.650)、香蕉(OR=0.656)、芹菜(OR=0.515)、茄子(OR=0.652)可能是银屑病发病的保护因素。结论：吸烟、嗜酒、鱼虾、羊肉、牛肉、辣椒、面粉、肥胖、洋葱、咸菜酸菜可作为独立危险因素,对银屑病的发病有一定的影响。大米、粗粮、鸡蛋、鲜奶、苹果、香蕉、芹菜、茄子可能对银屑病的发病起保护作用。
[Abstract]:Part one study on the changes of intestinal mucosal permeability in patients with psoriasis. Objective: to study the changes of intestinal mucosal permeability in patients with psoriasis and explore the pathogenesis of psoriasis. Methods: in 40 patients with psoriasis vulgaris, the concentrations of lactulose 10 g and mannitol 5 g / L were determined by high performance liquid chromatography (HPLC). The ratio of the two was calculated and the L / M value of the patients after the skin lesions had basically subsided was measured. 20 healthy adults were used as the control. Results: the ratio of L / M in psoriatic patients was 0.070 卤0.026, which was significantly higher than that in normal controls (0.029 卤0.006) and in the same group (0.036 卤0.009). Conclusion: the intestinal mucosal permeability in the patients with psoriasis vulgaris is higher than that in the normal subjects and the patients whose lesions have subsided, which may be related to the occurrence and development of psoriasis. The second part of the study on the relationship between the status of psoriasis and diet. Objective: to explore the dietary factors and other related factors affecting the condition of psoriasis. Methods: a 1: 1 matched case-control study was conducted to investigate the dietary and other related factors of 200 patients with psoriasis vulgaris. Univariate logistic regression analysis combined with multivariate conditional logist regression model was used. The results showed that the possible risk factors of the disease were: flour or 2.214g, beef order 3.308m, lamb chestnut 2.145m, fish and shrimps 1.952m, chilli 2.559m, onion Onion OR1.519g, smoking OR2.2515, drinking alcohol 2.20555, obesity OR1.5577, saltwater pickled vegetables OR1.752), regular consumption of rice and ornion 0.42222, coarse grain OR0.252, eggs 0.459, fresh milk 0.576o.0.576o.0.576o.0.576A, 0.576A, 0.576g, 0.576A, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576m, 0.576m, 0.576g / kg, 0.50,0.50,0.50,0.50,0.650respectively. The protective factors of psoriasis may be plantain Orchus 0.656, celery Orchus 0.515, eggplant Orchus 0.652), which may be the protective factor of psoriasis. Conclusion: smoking, alcoholism, fish and shrimp, mutton, beef, pepper, flour, obesity, onion, pickle and pickle can be independent risk factors for psoriasis. Celery and eggplant may play a protective role in the pathogenesis of psoriasis.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.63

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