青鹏软膏治疗双下肢慢性对称性湿疹疗效及其对皮肤屏障功能的影响

发布时间：2018-03-26 06:22

本文选题：湿疹　切入点：青鹏软膏　出处：《中国皮肤性病学杂志》2017年01期

【摘要】：目的评价青鹏软膏治疗慢性对称性湿疹的临床疗效和安全性,并观察患者皮肤屏障功能的改变情况。方法采用自身对照研究,对86例双下肢慢性对称性湿疹患者左下肢皮损外用青鹏软膏(治疗组),右下肢皮损外用糠酸莫米松乳膏(对照组),比较两组皮损治疗前和治疗4周时瘙痒、皮损严重程度和面积、湿疹病情指数(EASI)、皮肤生理功能,包括经表皮水分流失(TEWL)、角质层含水量(WCSC)和皮肤油脂(SC)及有效率。结果治疗4周后,两组皮损的瘙痒评分、皮损严重程度评分、皮损面积及EASI评分和TEWL均显著低于其治疗前,而WCSC和SC显著高于其治疗前,且治疗组靶皮损面积、皮损面积评分、皮损瘙痒评分、EASI评分和TEWL均显著低于对照组,但是治疗组靶皮损WCSC,SC和有效率均显著高于对照组,以上差异均有统计学意义(P均0.01)。结论青鹏软膏治疗慢性对称性湿疹安全有效,有利于皮肤屏障功能修复。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Qingpeng ointment in the treatment of chronic symmetric eczema and to observe the changes of skin barrier function. 86 patients with chronic eczema of lower extremities were treated with Qingpeng ointment (treatment group), and patients with right lower extremity skin lesion were treated with momethasone furoate cream (control group). The pruritus was compared between the two groups before and after 4 weeks of treatment. The severity and area of skin lesions, eczema disease index (EASI), skin physiological function, including transepidermal water loss (TEWL), cuticle moisture content (WCSCC) and skin grease SCC), and the effective rate. Results after 4 weeks of treatment, the pruritus scores of the two groups were evaluated. The scores of severity, area, EASI and TEWL were significantly lower than those before treatment, while WCSC and SC were significantly higher than those before treatment, and the target lesion area and lesion area score were significantly higher in the treatment group. The score of pruritus and TEWL in the treatment group were significantly lower than those in the control group, but the SC and the effective rate of the target skin lesion in the treatment group were significantly higher than those in the control group, and the differences were statistically significant (P < 0.01). Conclusion Qingpeng ointment is safe and effective in the treatment of chronic symmetric eczema. It is beneficial to the repair of skin barrier function.
【作者单位】：陕西省铜川市耀州区人民医院皮肤科;耀州区孙塬镇卫生院;
【分类号】：R758.23

【相似文献】