阿维A联合雷公藤多甙治疗掌跖脓疱病疗效观察

发布时间：2018-03-27 10:35

本文选题：阿维A　切入点：雷公藤多甙　出处：《吉林大学》2012年硕士论文

【摘要】：背景：掌跖脓疱病是一种病因尚未完全明了的发生于掌跖部位的慢性、复发性、炎症性疾病。多数人认为免疫学介导的发病机制在掌跖脓疱病的发生上起着重要的作用，但也有人认为本病是一种局限性脓疱型银屑病。本病的典型临床表现是在红斑基础上周期性发生的深在无菌性小脓疱,伴角化、脱屑。治疗方法多样主要有维甲酸类、免疫抑制剂、生物调节剂，，抗生素类以及物理疗法，但疗效都不十分满意。阿维A联合雷公藤多甙治疗掌跖脓疱病的国内相关报道较少。目的：观察阿维A联合雷公藤多甙治疗掌跖脓疱病疗效和安全分析。方法：搜集门诊患者102例，随机分成三组：分别为阿维A联合雷公藤多甙组、阿维A组、雷公藤多甙组，同时均外用复方丙酸氯倍他索软膏（商品名：金纽尔）疗程2月，然后根据各项治疗指标进行比较。结果：阿维A联合雷公藤多甙组治疗2个月后有效率明显高于另外两组（阿维A联合雷公藤多甙组为92.31%，阿维A组为64.52%，雷公藤多甙组为62.5%），阿维A联合雷公藤多甙组与阿维A组相比（X~2=9.092，P=0.0280.05）差异有统计学意义；阿维A联合雷公藤多甙组与雷公藤多甙组相比（X~2=11.084，P=0.0110.05）差异有统计学意义；阿维A组与雷公藤多甙组相比（X~2=0.575，P=0.902＞0.05)差异无统计学意义。结论：与单用阿维A或者雷公藤多甙相比两药联合应用治疗掌跖脓疱病疗效高，不良反应无明显增加。
[Abstract]:Background: palmoplantar pustulosis is a chronic, recurrent and inflammatory disease that occurs at palmar and metatarsal sites. Most people believe that immunopathogenesis plays an important role in the development of palmoplantar pustulosis. But some people also think that this disease is a kind of localized pustular psoriasis. The typical clinical manifestation of this disease is that it occurs periodically on the basis of erythema in the aseptic pustules, accompanied by keratosis, desquamation. The main treatment methods are retinoic acid. Immunosuppressants, biological modulators, antibiotics and physiotherapy are not very satisfactory. There are few reports on the treatment of palmoplantar pustulosis with avea combined with tripterygium wilfordii polyglycosides. Objective: to observe the efficacy and safety of avea combined with tripterygium wilfordii polyglycoside in the treatment of palmoplantar pustulosis. Methods: 102 outpatients were randomly divided into three groups: Avera combined with tripterygium wilfordii polyglycosides group, avea group, tripterygium wilfordii polyglycoside group, and were treated with compound clobetasol propionate ointment for 2 months. Then according to the treatment indicators were compared. Results: after 2 months treatment, the effective rate of avea combined with tripterygium wilfordii polyglycoside group was significantly higher than that of the other two groups (92.31% in the avea combined with tripterygium wilfordii polyglycoside group, 64.52% in the avea group, 62.5% in the tripterygium wilfordii polyglycoside group). There was significant difference between group A and group A (P 0.0280.05). There was no significant difference between Avera and Tripterygium wilfordii polyglycosides group and Tripterygium wilfordii polyglycoside group compared with tripterygium wilfordii polyglycoside group (P < 0.01), but there was no significant difference between Avera group and Tripterygium wilfordii polyglycoside group (P < 0.05). Conclusion: compared with Avera or Tripterygium wilfordii polyglycosides alone, the combined treatment of palmoplantar pustulosis is more effective than that of tripterygium wilfordii.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R753

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