中药联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中的临床应用

发布时间：2018-03-29 07:48

本文选题：恶性黑色素瘤　切入点：术后辅助治疗　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨中药联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中的作用;方法:患者无其他疾患情况下予以大剂量干扰素α-2b(甘乐能)治疗(1200IU皮下注射,每日一次,连续7日。三月一疗程,连续8个疗程)。治疗过程中注意观察患者白细胞的数量,如低于正常则予以升白细胞的药物,如果患者出现发热则予以降温治疗对20例皮肤恶性黑色瘤术后患者使用大剂量干扰素α-2b(甘乐能)治疗(1200IU皮下注射,每日1次,一个疗程连续7天。每隔3月为1疗程,连续8个疗程)和中药人参皂苷(0.25g,饭前1小时口服,每日2次,每月服用三周)。结果:20例患者中有1例患者没有按时进行治疗而死亡,其余患者从2012年至今未见死亡,治疗过程中发现局部以及远处转移的病灶均消失。结论:采用外科的手术切除真对恶性黑色素瘤肿瘤原发部位的主要的处理手段,术后空缺区时的进行填补和重新建立。对于那些不理证实存在恶性黑色素瘤周围淋巴结转移的情况,可以进行淋巴结清扫治疗。我们采用人参皂苷辅助治疗取得较好的疗效,有望进一步临床研究。中药联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中起到重要的作用。
[Abstract]:Objective: to investigate the effect of Chinese medicine combined with high dose interferon on postoperative adjuvant treatment of cutaneous malignant melanoma. For 7 consecutive days, a course of treatment for three months, eight consecutive courses of treatment. During the course of treatment, attention was paid to observing the number of white blood cells in patients, and if they were below normal, they were given drugs to raise white blood cells. If the patient had fever, 20 patients with malignant melanoma of skin were treated by subcutaneous injection of high-dose interferon 伪 -2b (glycine), once a day for 7 consecutive days, and every three months as a course of treatment. And ginseng saponins 0.25g, one hour before meals, twice a day, three weeks a month. The results showed that one out of 20 patients died without timely treatment, and the rest had not died since 2012. It was found that both local and distant metastatic lesions disappeared during the treatment. Conclusion: surgical resection is the main treatment for the primary site of malignant melanoma. For those cases where lymph node metastasis around malignant melanoma is confirmed, lymph node dissection can be performed. We use ginsenoside adjuvant therapy to get better effect. Chinese medicine combined with high dose interferon may play an important role in postoperative adjuvant treatment of cutaneous malignant melanoma.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.5

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