病毒性皮肤病患者外周血淋巴细胞亚群的检测分析

发布时间：2018-03-29 09:08

本文选题：病毒性皮肤病　切入点：淋巴细胞亚群　出处：《中国皮肤性病学杂志》2016年01期

【摘要】：目的探讨病毒性皮肤病患者的免疫功能状态。方法应用流式细胞仪分析检测486例病毒性皮肤病患者外周血中的淋巴细胞亚群,并与正常人进行比较。结果病毒性皮肤病患者之间外周血淋巴细胞亚群比较,CD4~+T细胞,CD8~+T细胞,CD3~-CD19~+细胞,CD3~-CD16~+56~+NK细胞,CD4~+/CD8~+差异有统计学意义(P0.05)。单纯疱疹患者组与带状疱疹患者组比较,CD8~+T细胞,CD3~-CD16~+56~+NK细胞,CD4~+/CD8~+差异有统计学意义(P0.05)。寻常疣患者组、扁平疣患者组与尖锐湿疣患者组三组相比较,CD4~+T细胞、CD8~+T细胞、CD3~-CD19~+细胞、CD3~-CD16~+56~+NK细胞差异也有统计学意义(P0.05)。与正常组相比较,五种病毒性皮肤病患者组CD3~+T细胞、CD4~+T细胞、CD8~+T、CD4~+/CD8~+细胞除带状疱疹患者组,CD3~-CD19~+细胞仅尖锐湿疣患者组,CD3~-CD16~+56~+NK细胞除尖锐湿疣患者组外差异均有统计学意义(P0.05)。结论各类病毒性皮肤病患者均存在不同程度的免疫异常。免疫功能的紊乱是病毒性皮肤病患者发病的一个重要机制,在各类病毒性皮肤病患者的发生、发展过程中可能起到重要的作用。
[Abstract]:Objective to investigate the immune function of patients with viral dermatosis. Methods the lymphocyte subsets in peripheral blood of 486 patients with viral dermatosis were detected by flow cytometry. Results the subsets of peripheral blood lymphocytes in patients with viral dermatosis were compared with those in normal controls. There was a significant difference between herpes simplex group and herpes simplex group. The difference of CD4 ~ / CD8- NK cell CD4 ~ / / CD8 ~ ~ in patients with herpes vulgaris was statistically significant (P < 0.05), and there was no significant difference between the patients with verruca vulgaris, the patients with verruca vulgaris, the patients with herpes vulgaris. There was also a significant difference in CD4T cells between the flat verruca patients group and the condyloma acuminatum group (P 0.05), and the difference between the CD4 ~ T cells and the CD8 ~ T cells in the patients with flat verruca and condyloma acuminatum. CD3 ~ T cells in patients with five viral dermatoses, CD4 ~ T cells and CD8 ~ / / CD8 ~ cells in patients with herpes zoster were significantly different from those in patients with condyloma acuminatum except for those with condyloma acuminatum. Conclusion there is a significant difference in the number of CD3 ~ T cells between patients with condyloma acuminatum and patients with condyloma acuminatum except for those with condyloma acuminatum (P 0.05). All patients with viral dermatosis have different degrees of immune abnormalities. The disorder of immune function is an important mechanism for the pathogenesis of viral dermatosis. It may play an important role in the occurrence and development of various viral skin diseases.
【作者单位】：沈阳市第七人民医院皮肤科;
【分类号】：R752

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