幽门螺杆菌感染与荨麻疹的相关性研究

发布时间：2018-03-31 02:35

本文选题：荨麻疹　切入点：幽门螺杆菌　出处：《中华医院感染学杂志》2014年05期

【摘要】：目的研究荨麻疹与幽门螺杆菌(Hp)感染的相关性并分析相关的预防措施,为降低临床荨麻疹患者感染幽门螺杆菌提供参考资料。方法选取2010年1月-2012年9月门诊治疗的荨麻疹患者120例,并随机选取同期体检的正常人群120名,对两组进行血清抗Hp-IgG抗体检测,观察两组患者Hp阳性情况,将80例荨麻疹Hp阳性患者随机分为试验组43例和对照组37人,对照组患者应用常规荨麻疹治疗,试验组患者在对照组基础上应用三联疗法(阿莫西林+克拉霉素+奥美拉唑),观察并对比试验组与对照组的疗效。结果荨麻疹组Hp阳性80例占66.67%,正常组Hp阳性44人占36.67%;经治疗后,试验组的Hp转阴率达86.05%,对照组Hp转阴率达到70.27%;试验组显效8例,好转17例,总有效率为86.05%;对照组显效3例,好转7例,总有效率78.38%;上述数据差异均有统计学意义(P0.05)。结论慢性荨麻疹与Hp的感染有相关性,预防措施主要针对过敏原进行,有效降低感染率。
[Abstract]:Objective to study the correlation between urticaria and Helicobacter pylori (HP) infection and to analyze the preventive measures. Methods 120 patients with urticaria who were treated in outpatient clinic from January 2010 to September 2012 were selected and 120 healthy subjects were randomly selected. Serum anti Hp-IgG antibody was detected in two groups. 80 patients with HP positive urticaria were randomly divided into experimental group (n = 43) and control group (n = 37). Patients in control group were treated with routine urticaria. The patients in the test group were treated with triplex therapy (amoxicillin clarithromycin omeprazole) on the basis of the control group. The curative effects of the test group and the control group were observed and compared. Results 80 cases of HP positive in urticaria group accounted for 66.67% and 44 cases were positive for HP in the normal group. The proportion of people is 36.67; after treatment, The negative rate of HP in the test group was 86.05 and that in the control group was 70.27; in the test group, there were 8 cases of remarkable effect and 17 cases of improvement, the total effective rate was 86.05; in the control group, there were 3 cases of remarkable effect and 7 cases of improvement. The total effective rate was 78.38, and the differences were statistically significant (P 0.05). Conclusion there is a correlation between chronic urticaria and HP infection, and the preventive measures are mainly aimed at allergens, which can effectively reduce the infection rate.
【作者单位】：莱芜市人民医院皮肤科;
【基金】：莱芜市科研基金资助项目(鉴字2005-043)
【分类号】：R758.24

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