SLP-2蛋白在皮肤鳞状细胞癌中的表达及意义

发布时间：2018-04-01 18:07

本文选题：鳞状细胞癌　切入点：SLP-　出处：《中国皮肤性病学杂志》2014年09期

【摘要】：目的探讨SLP-2在皮肤鳞状细胞癌中的表达及其与临床病理参数间的相关性。方法免疫组织化学法观察50例皮肤鳞状细胞癌和30例脂溢性角化病组织蜡片中SLP-2的表达,分析SLP-2蛋白的表达与皮肤鳞状细胞癌临床病理变量之间的关系。结果 SLP-2蛋白在脂溢性角化、皮肤鳞状细胞癌中的阳性表达率分别为6.67%和74.00%。SLP-2蛋白的表达与皮肤鳞癌的病理分级、临床分期及淋巴结转移密切相关。结论 SLP-2蛋白的过表达可能与皮肤鳞状细胞癌的发生发展密切相关。
[Abstract]:Objective to investigate the expression of SLP-2 in cutaneous squamous cell carcinoma (SCC) and its correlation with clinicopathological parameters.Methods the expression of SLP-2 in paraffin tablets of 50 cases of cutaneous squamous cell carcinoma and 30 cases of seborrheic keratosis was observed by immunohistochemical method. The relationship between the expression of SLP-2 protein and clinicopathological variables of cutaneous squamous cell carcinoma was analyzed.Results the positive expression rates of SLP-2 protein in seborrheic keratosis and cutaneous squamous cell carcinoma were 6.67% and 6.67%, respectively. The expression of 74.00%.SLP-2 protein was closely related to the pathological grade, clinical stage and lymph node metastasis of cutaneous squamous cell carcinoma.Conclusion overexpression of SLP-2 protein may be closely related to the occurrence and development of cutaneous squamous cell carcinoma.
【作者单位】：复旦大学附属金山医院皮肤科;复旦大学附属肿瘤医院病理科;复旦大学附属金山医院病理科;
【分类号】：R739.5

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