血清IL-31水平与慢性自发性荨麻疹患者的疾病严重程度和瘙痒的相关性研究

发布时间：2018-04-01 20:14

本文选题：慢性自发性荨麻疹　切入点：白细胞介素-31　出处：《山西医科大学》2017年硕士论文

【摘要】：目的:采用视觉模拟量表、连续7天荨麻疹活动度量表及慢性荨麻疹生活质量量表对患者进行调查,探讨慢性自发性荨麻疹患者血清中IL-31表达水平与荨麻疹严重程度、瘙痒及生活质量的相关性。方法:收集2016年6月~2016年12月,就诊于山西医科大学第一医院皮肤科并确诊为慢性自发性荨麻疹患者61例和同期随机在我院健康体检者59例的临床一般资料及外周血标本,所有患者均符合慢性自发性荨麻疹诊断标准。采用ELISA法检测所有标本中血清IL-31的含量,通过瘙痒持续时间、视觉模拟量表、连续7天荨麻疹活动度量表及慢性荨麻疹生活质量量表等获取临床资料。采用SPSS22.0软件对数据进行处理,得到患者血清中IL-31与瘙痒、荨麻疹严重程度和生活质量的相关性。结果:对照组IL-31水平为(1.74±0.30pg/ml),研究组IL-31水平为(28.63±15.38pg/ml),两组相比差异具有统计学意义(Z=-9.095,P0.001)。CSU患者轻度、中度及重度瘙痒组之间IL-31水平差异有统计学意义(P0.05)。CSU患者瘙痒持续时间30min组、瘙痒持续时间30min-120min组、瘙痒持续时间120min组之间IL-31水平差异没有统计学意义(P=0.238);疾病严重程度与CSU患者IL-31水平呈正相关(r值为0.665,P0.001)。患者生活质量与IL-31水平呈正相关(r值为0.569,P0.001)。结论:IL-31在CSU患者血清中的表达升高,且与瘙痒程度、疾病严重程度及生活质量呈正相关,而与瘙痒持续时间无相关性,表明IL-31可能参与CSU的发病,并可能与其瘙痒有关。IL-31有可能成为评估CSU严重程度及对生活质量影响的指标,为临床诊疗提供指导。
[Abstract]:Objective: to investigate the expression of IL-31 and the severity of urticaria in patients with chronic urticaria by using visual analogue scale, activity scale for 7 days and quality of life scale for chronic urticaria. The correlation between itching and quality of life. Methods: from June 2016 to December 2016, Clinical general data and peripheral blood samples of 61 patients with chronic spontaneous urticaria diagnosed in the Department of Dermatology, first Hospital of Shanxi Medical University and 59 cases of random physical examination in our hospital at the same time. All patients met the diagnostic criteria for chronic spontaneous urticaria. Serum IL-31 levels were measured by ELISA method. The clinical data were obtained by urticaria activity scale and chronic urticaria quality of life scale for 7 days. The data were processed by SPSS22.0 software and the IL-31 and pruritus in serum were obtained. Results: the level of IL-31 in the control group was 1.74 卤0.30pg / ml, and the IL-31 level in the study group was 28.63 卤15.38pg / ml. The difference between the two groups was statistically significant. There were significant differences in IL-31 levels between moderate and severe pruritus groups. There were significant differences between 30min group and 30min-120min group. There was no significant difference in IL-31 level between 120min group and CSU group, and there was a positive correlation between the severity of the disease and IL-31 level in CSU patients. There was a positive correlation between quality of life (QOL) and IL-31 level in patients with CSU. Conclusion IL-V31 is positively correlated with the level of IL-31 in patients with CSU. The expression in Qing Dynasty was increased, There was a positive correlation with the degree of pruritus, severity of disease and quality of life, but no correlation with the duration of pruritus, indicating that IL-31 may be involved in the pathogenesis of CSU. It may be related to itching. IL-31 may be an index to evaluate the severity of CSU and its impact on quality of life, and provide guidance for clinical diagnosis and treatment.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.24

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