雷公藤多苷片对泛发性湿疹患者外周血嗜酸性粒细胞的影响

发布时间：2018-04-08 18:18

本文选题：泛发性　切入点：湿疹　出处：《中国皮肤性病学杂志》2017年02期

【摘要】：目的观察雷公藤多苷片对泛发性湿疹患者外周血嗜酸性粒细胞的影响,以探讨其对泛发性湿疹患者治疗的作用机制。方法对入选的60例泛发性湿疹患者,治疗前行外周血嗜酸性粒细胞(EOS)检测,EOS值增高者记录其临床总积分值,每天按照雷公藤多苷片1mg/(kg·d)分为2~3次口服,治疗4周后再次检测其外周血EOS,并记录其临床总积分值。随机匹配健康对照组30例,检测、记录外周血EOS。结果 60例泛发性湿疹患者中,32例外周血EOS绝对值高于正常值,与对照组相比,差异有统计学意义(P0.05),经过雷公藤多苷片治疗4周后,EOS数及临床总积分值明显降低,与治疗前相比,差异有统计学意义(P0.05)。对照组30例,嗜酸性粒细胞27例正常,3例轻度增高。结论泛发性湿疹患者EOS绝对值显著增高,雷公藤多苷片能明显降低其外周血EOS及临床总积分值。
[Abstract]:Objective to investigate the effect of Tripterygium wilfordii polyglycoside tablets on eosinophils in peripheral blood of patients with generalized eczema.Methods 60 patients with generalized eczema were enrolled. Patients with elevated eosinophil EOS in peripheral blood before treatment were recorded their total clinical scores, and were divided into 23 oral doses according to tripterygium wilfordii polyglycoside tablets (1mg/(kg d) daily.After 4 weeks of treatment, the peripheral blood EOS was measured again and the total clinical score was recorded.EOSs in peripheral blood were measured and recorded in 30 healthy subjects.Results the absolute value of EOS in peripheral blood of 32 patients with generalized eczema was higher than that of the control group (P 0.05). After 4 weeks of treatment with tripterygium wilfordii polyglycoside tablets, the number of EOS and the total clinical integral value were significantly decreased.Compared with before treatment, the difference was statistically significant (P 0.05).In the control group, 30 cases, 27 cases of eosinophil were normal and 3 cases had slight increase of eosinophils.Conclusion the absolute value of EOS in patients with generalized eczema was significantly increased. Tripterygium wilfordii polyglycoside tablets could significantly reduce the peripheral blood EOS and the total clinical score.
【作者单位】：兰州大学第二医院定西医院皮肤科;
【分类号】：R758.23

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