凋亡抑制基因Livin和血管内皮生长因子在寻常疣和尖锐湿疣中的表达

发布时间：2018-04-10 07:10

本文选题：尖锐湿疣　切入点：寻常疣　出处：《中国皮肤性病学杂志》2014年06期

【摘要】：目的观察Livin和血管内皮生长因子(vascular endothelial growth factor,VEGF)在寻常疣以及尖锐湿疣组织中的表达情况,探讨其在人类乳头瘤病毒感染所致皮肤疾病中的意义。方法收集30例寻常疣、30例尖锐湿疣及20例正常皮肤组织标本,采用免疫组化SP法检测Livin和VEGF在该3组标本组织中的表达情况。结果尖锐湿疣、寻常疣和正常包皮组织中Livin的表达阳性率分别为83.33%,60.00%和30.00%,表达强度依次为(2+)～(3+)、(-)～(2+)和(-)～(+)。而且该3组标本组织中均表达VEGF,阳性率均为100.00%。尖锐湿疣中VEGF表达强度多数为(2+～3+),其他两组中表达强度多数为(+～2+)。三组标本组织中Livin和VEGF阳性表达率的差异均有统计学意义(P均0.01),且CA组织中Livin与VEGF表达呈正相关(P0.01)。结论尖锐湿疣组织中存在Livin和VEGF过表达,其过表达可能对尖锐湿疣发生发展有一定的作用。
[Abstract]:Objective To observe the effects of Livin and vascular endothelial growth factor (vascular endothelial, growth factor, VEGF) expression in verruca vulgaris and condyloma acuminatum tissues, to explore its significance in the skin disease caused by human papillomavirus infection. Methods 30 cases of verruca vulgaris, 30 cases of condyloma acuminatum and 20 cases of normal skin tissues, the expression of in the 3 groups of specimens of Livin and VEGF by immunohistochemical detection of SP method. Results the positive expression rate of Livin in condyloma acuminatum, verruca vulgaris and normal foreskin tissues were 83.33%, 60% and 30%, the expression intensity according to the times (2+) ~ (3+), (-) ~ (2+) and (-) ~ (+). The expression of VEGF was 3 and the group of specimens, the positive rate was 100.00%. the expression of VEGF in condyloma acuminatum (2+ ~ 3+) for most of the other two groups, the expression intensity of the majority (2+ ~ +). The difference in Livin and VEGF groups were positive expression rate the three group All of them were statistically significant (P = 0.01), and there was a positive correlation between Livin and VEGF expression in CA tissues (P0.01). Conclusion Livin and VEGF overexpression in condyloma acuminatum tissues, and its over expression may play a certain role in the occurrence and development of condyloma acuminatum.

【作者单位】：宁波大学医学院附属医院;宁波市明州医院;
【基金】：宁波大学校级课题(编号:xyy12007)
【分类号】：R752.53

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