可调脉宽倍频Nd：YAG激光治疗皮肤血管性疾病的疗效及安全性观察

发布时间：2018-04-10 15:10

本文选题：可调脉宽倍频Nd:YAG激光 + 皮肤血管性疾病　；参考：《汕头大学》2010年硕士论文

【摘要】：背景和目的随着光热选择性理论的提出,各种新型美容激光机相继出现,使皮肤血管性疾病的治疗更安全有效。本研究拟通过观察美国科医人公司生产的维纳斯四合一激光机可调脉宽倍频Nd:YAG激光治疗皮肤血管性疾病(包括毛细血管扩张症、血管角皮瘤、会阴部血管瘤),评价其疗效及安全性。方法采用可调脉宽倍频Nd:YAG激光治疗毛细血管扩张症125例、血管角皮瘤24例、会阴部血管瘤2例,治疗参数:波长532nm,能量12-24J/cm2,光斑直径3-4mm,脉宽10-20ms。每个患者每次治疗前均拍照存档,本研究通过对比患者治疗前后的相片对疗效等级进行评估,并电话随访其有无副作用出现及复发情况。并用卡方检验毛细血管扩张症患者不同治疗次数有效率及治愈率的差异是否有显著性、颜面部及酒渣鼻性毛细血管扩张症治愈率的差异是否有显著性。结果 125例毛细血管扩张症患者中,应用可调脉宽倍频Nd:YAG激光治疗1-5次后,痊愈95例,显效30例,治愈率76.00%,有效率达100.00%。比较毛细血管扩张症患者不同治疗次数有效率及治愈率的差异是否有显著性显示:1次与2次及2次与5次治疗的有效率、1次与2次及2次与3次治疗的治愈率有显著性差异;2次、3次及4次治疗的有效率、3次、4次及5次治愈率无显著性差异。颜面部及酒渣鼻性毛细血管扩张症的治愈率有显著性差异,前者治愈率较高。仅有2例患者出现暂时性色素沉着,均无遗留瘢痕。24例血管角皮瘤患者中,应用可调脉宽倍频Nd:YAG激光治疗1-5次后,治愈24例,治愈率达100%,均未出现色素沉着、瘢痕或感染等副作用。2例会阴部血管瘤患儿分别治疗3、5次治愈,未出现色素沉着、瘢痕等副作用。电话随访半年均无复发。结论维纳斯可调脉宽倍频Nd:YAG激光治疗毛细血管扩张症、血管角皮瘤安全有效,值得在临床中推广应用。维纳斯可调脉宽倍频Nd:YAG激光可用于治疗会阴部血管瘤。毛细血管扩张症患者经过2次治疗取得明显效果,经过3次治疗大多治愈。随着治疗次数增加有效率及治愈率有所提高,但统计学处理无显著性差异。颜面部毛细血管扩张症比酒渣鼻性毛细血管扩张症的治愈率高。
[Abstract]:Background and purposeWith the development of the theory of photothermal selectivity, a variety of new beauty laser machines have emerged, which make the treatment of skin vascular diseases safer and more effective.The purpose of this study was to observe the treatment of cutaneous vascular diseases (including capillary angiectasia, angioceratoma) by observing the adjustable pulse width doubling Nd:YAG laser produced by American Medical Company.To evaluate the efficacy and safety of perineal hemangioma.Method125 cases of capillary angiectasis, 24 cases of hemokeratoma and 2 cases of perineal hemangioma were treated with adjustable pulse width doubling Nd:YAG laser. The treatment parameters were: wavelength 532 nm, energy 12-24 J / cm 2, spot diameter 3 ~ 4 mm, pulse width 10 ~ 20 Ms.Each patient was photographed and archived before and after treatment. In this study, the curative effect was evaluated by comparing the images of the patients before and after treatment, and the occurrence and recurrence of side effects were followed up by telephone.Chi-square was used to test whether there were significant differences in the effective rate and cure rate of different treatment times in patients with capillary dilatation and whether there was significant difference in the cure rate of facial part and rosacea capillary vasectasis.ResultAmong the 125 cases of capillary dilatation, 95 cases were cured and 30 cases had remarkable effect after 1-5 times treatment with adjustable pulse width doubling Nd:YAG laser. The cure rate was 76.00 and the effective rate was 100.00000.To compare the effective rate and cure rate of different treatment times and cure rate in capillary dilatation patients showed that the cure rate of 1 and 2 times and 2 times and 5 times of treatment of 1 and 2 times and 2 times and 5 times of treatment with 1 and 2 times and 2 times and 3 times of treatment showed that there was a significant difference in the cure rate of 1 and 2 times and 2 times and 3 times of treatment.There was no significant difference in the effective rate of 3 times, 4 times and 5 times in the treatment of 2 times and 4 times, and there was no significant difference in the cure rate of 3 times, 4 times and 5 times of treatment.The cure rate of facial part and rosacea capillary dilatation was significantly different, the former had higher cure rate.There were only 2 cases of temporary pigmentation, none of them had any scar. 24 cases of hemangikeratoma were treated with adjustable pulse width doubling frequency Nd:YAG laser for 1-5 times, 24 cases were cured, the cure rate was 100%, and none of them had pigmentation.2 cases of hemangioma of pudendal region were treated with scar or infection for 5 times, without pigmentation, scar and other side effects.There was no recurrence in telephone follow-up for half a year.ConclusionVenus adjustable pulse width doubling Nd:YAG laser is safe and effective in the treatment of capillary angiectasis, which is worth popularizing in clinic.Venus adjustable pulse width doubling Nd:YAG laser can be used in the treatment of perineal hemangioma.Capillary dilatation patients after 2 times of treatment achieved obvious results, after 3 times of treatment mostly cured.The effective rate and cure rate increased with the increase of treatment times, but there was no significant difference in statistical treatment.The cure rate of facial capillary dilatation is higher than that of rosacea capillary dilatation.
【学位授予单位】：汕头大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.6

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