老年可疑梅毒患者血清Tp15,Tp17,Tp45和Tp47抗体表达分析

发布时间：2018-04-15 23:26

本文选题：梅毒 + 梅毒螺旋体特异性抗体　；参考：《中国皮肤性病学杂志》2014年09期

【摘要】：目的分析老年可疑梅毒患者血清Tp15,Tp17,Tp45和Tp47抗体表达特征。方法性病门诊收集24例梅毒螺旋体颗粒凝集试验(TPPA)阳性的老年可疑梅毒患者,同时收集35例老年二期梅毒患者和22例治疗10年以上的老年梅毒患者作为对照组,采用欧盟免疫印迹法检测各组患者血清抗梅毒螺旋体Tp15,Tp17,Tp45和Tp47 IgG表达情况。结果二期梅毒患者4种螺旋体特异性抗体均阳性。与老年二期梅毒患者相比,治疗10年以上的老年梅毒患者Tp17和Tp47 IgG抗体表达下降(P均0.001);老年可疑梅毒患者与治疗10年以上的老年梅毒患者血清Tp15,Tp17,Tp45和Tp47 IgG抗体表达差异无统计学意义(P均0.05)。结论梅毒治疗后Tp17和Tp47 IgG抗体表达下降;TPPA阳性的老年可疑患者可能是早年感染的梅毒患者。
[Abstract]:Objective to analyze the expression of serum Tp15, Tp17, Tp45 and Tp47 antibodies in elderly patients with suspected syphilis.Methods Twenty-four elderly suspected syphilis patients with TPPA-positive Treponema pallidum granulocyte agglutination test were collected from STD outpatient clinic. 35 elderly patients with secondary syphilis and 22 elderly syphilis patients treated for more than 10 years were collected as control group.The expression of Tp15, Tp17, Tp45 and Tp47 IgG in serum of patients with Treponema pallidum was detected by European Union Western blotting.Results all the patients with secondary syphilis were positive for the specific antibodies of four kinds of Treponema pallidum.Compared with the elderly patients with secondary syphilis,The antibody expression of Tp17 and Tp47 IgG in elderly syphilis patients treated for more than 10 years was decreased (P 0.001), while there was no significant difference in the expression of serum Tp15, Tp17, Tp45 and Tp47 IgG antibodies between the elderly patients with suspected syphilis and those with aged syphilis over 10 years.Conclusion the suspected elderly patients with Tp17 and Tp47 IgG positive expression after syphilis treatment may be early infected syphilis patients.
【作者单位】：中国医学科学院北京协和医学院皮肤病研究所;
【基金】：江苏省省临床医学科技专项-江苏省临床医学研究中心项目“若干皮肤病省内诊疗体系建设与转化医学研究”(BL2012003)
【分类号】：R759.1

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