强脉冲光结合氨基乙酰丙酸治疗痤疮的临床观察

发布时间：2018-04-20 00:40

本文选题：炎症性痤疮 + 光动力　；参考：《中国美容医学》2009年08期

【摘要】：目的:观察强脉冲光(intense pulsed light,IPL)结合氨基乙酰丙酸(aminolevulinic acid,ALA)-光动力疗法(photodynamic therapy,PDT)治疗炎症性痤疮的疗效及安全性。方法:选取10名中重度炎症性痤疮患者,左右侧面部随机分为治疗侧(IPL结合ALA-PDT治疗)及对照侧(单纯IPL治疗),共治疗3次,治疗间隔时间4周。治疗结束后,由医生及受试者进行主观评价;应用非创伤性仪器检测皮肤亮度(lightness,L值)、皮脂含量及角质层含水量。结果:治疗侧与对照侧皮损消退率分别为74.3%和49.6%,有效率80.0%和50.0%,满意率80%和30%。治疗侧L值显著升高(P0.05),皮脂含量显著减少(P0.05)。两种治疗对角质层含水量均无显著影响。副作用包括短暂且可耐受的轻微红肿、发热或局部刺痛感。结论:I PL结合ALA-PDT治疗炎症性痤疮疗效好,副作用小。
[Abstract]:Objective: to observe the efficacy and safety of intense pulse pulsed (pulsed) combined with aminolevulinic acidic acid (ALA-PDT) in the treatment of inflammatory acne. Methods: ten patients with moderate and severe inflammatory acne were randomly divided into two groups: the treated side was treated with ALA-PDT and the control side (treated with IPL alone) for 3 times. The interval between treatment and treatment was 4 weeks. After treatment, the subjective evaluation was carried out by doctors and subjects, and the skin brightness lightnessl value, sebum content and cuticle water content were measured by non-traumatic instrument. Results: the receding rate of skin lesions in the treatment side and the control side was 74.3% and 49.6%, the effective rate was 80.0% and 50.0%, and the satisfaction rate was 80% and 30%. The L value of the treated side increased significantly (P 0.05), and the sebum content decreased significantly (P 0.05). The two treatments had no significant effect on the water content of cuticle. Side effects include transient and tolerable mild redness, fever, or local tingling. Conclusion the treatment of inflammatory acne with ALA-PDT combined with 1: I PL has good curative effect and little side effect.
【作者单位】：中国医科大学附属第一医院皮肤科;
【基金】：2007年教育部创新团队基金(IRT0760)
【分类号】：R758.733

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