养血祛风汤联合盐酸西替利嗪治疗血虚风燥型慢性荨麻疹的临床观察

发布时间：2018-04-20 13:44

  本文选题：慢性荨麻疹 + 血虚风燥型　； 参考：《湖北中医药大学》2010年硕士论文

【摘要】： 慢性荨麻疹是皮肤科的常见多发疾病,据临床报道统计,约有20%的人一生中都患过慢性荨麻疹。慢性荨麻疹的皮损主要为时隐时现的风团,因其经常反复性的发作、剧痒难忍,进而严重影响到患者的工作、学习和生活。患者要长期服用抗组胺药才能控制病情,但停药后病情很快容易复发。所以,防治慢性荨麻疹是我们医护人员义不容辞的责任。目前,西医治疗该病主要是对症支持治疗,经常予以抗组胺药等内服,但副作用较大,且停药较容易复发。我们运用养血祛风汤联合盐酸西替利嗪内服治疗慢性荨麻疹取得了较好的疗效。通过本次临床研究,目的在于观察养血祛风汤联合盐酸西替利嗪治疗血虚风燥型慢性荨麻疹的临床疗效情况以及其复发情况,从而为此治疗方法在以后的临床推广运用提供依据。 所有病例均来源于2008年8月至2009年5月湖北省中医院皮肤科门诊患者,共收集患者60例,均为血虚风燥型的慢性荨麻疹属患者。将这60例患者随机分成治疗组和对照组,各30例。两组在以下几个方面(年龄、性别及病程)经统计学比较,差异均无统计学意义(P0.05),具有可比性。治疗组运用养血祛风汤煎汁服用,每次150ml,每日2次及口服盐酸西替利嗪分散片10mg,每日1次。饭后服用。对照组口服盐酸西替利嗪分散片10mg,每日1次及口服祛风止痒口服液10ml,每日3次。均饭后服用。两组疗程均为四周。服药期间均停用一切其他药物。 疗效评价标准：以症状积分下降指数作为评判标准,症状积分下降指数=[(治疗前积分-治疗后积分)/治疗前积分]×100%。痊愈指标：指数≥90%；显效指标：90%指数≥60%；有效指标：60%指数≥30%；无效指标：指数30%。 4.1两组临床疗效比较,经过统计学处理,治疗组(养血祛风汤联合盐酸西替利嗪)疗效优于对照组(盐酸西替利嗪联合祛风止痒口服液),具有统计学意义(P＜0.05)。 4.2两组瘙痒程度治疗后的评分比较,经过统计学处理,治疗组疗效优于对照组,具有统计学意义(P0.05)。 4.3两组临床观察治疗后的总积分比较,经过统计学处理,治疗组疗效优于对照组,具有统计学意义(P0.05)。 4.4两组复发率比较,经过统计学处理,治疗组疗效优于对照组,具有统计学意义(P0.05)。 通过对本次试验的临床观察,可以证实养血祛风汤联合盐酸西替利嗪治疗血虚风燥型慢性荨麻疹：①其疗效优于盐酸西替利嗪组,②同时其安全性高,毒副反应小,经济适用,为临床治疗慢性荨麻疹提供了有效的方法。
[Abstract]:Chronic urticaria is a common disease in dermatology. According to clinical report, about 20% of people have had chronic urticaria in their lifetime. The skin lesion of chronic urticaria is mainly a wind mass which is often repeated and itching is hard to bear, which seriously affects the work, study and life of the patients. Patients must take long-term antihistamine to control the condition, but soon after withdrawal of the disease recurrence. Therefore, the prevention and treatment of chronic urticaria is our medical staff's unshirkable responsibility. At present, western medicine treatment is mainly for symptomatic support therapy, often given antihistamine drugs, but the side effects are larger, and withdrawal of drugs is easy to relapse. We used Yangxue Qufeng decoction combined with cetirizine hydrochloride to treat chronic urticaria. The purpose of this clinical study was to observe the clinical efficacy and recurrence of Yangxue Qufeng decoction combined with cetirizine hydrochloride in the treatment of chronic urticaria with blood deficiency and wind dryness. Therefore, the treatment method in the future clinical application to provide the basis. All the cases were from the dermatology department of Hubei traditional Chinese Medicine Hospital from August 2008 to May 2009. A total of 60 cases of chronic urticaria with blood deficiency and wind dryness were collected. The 60 patients were randomly divided into treatment group and control group, 30 cases each. There was no significant difference between the two groups in the following aspects (age, sex and course of disease). The treatment group was treated with Yangxue Qufeng decoction, 150 ml twice a day and 10 mg of cetirizine hydrochloride dispersible tablets once a day. Take it after meals. The control group was treated with 10 mg cetirizine hydrochloride dispersible tablets once a day and 10 ml qufeng Zhiyang oral solution 3 times a day. Take after meals. The course of treatment in both groups was four weeks. All other drugs were discontinued during medication. Evaluation criteria of curative effect: the symptom integral drop index was taken as the criterion, the symptom integral drop index = [(pre-treatment integral-post-treatment integral / pre-treatment integral)] 脳 100. Recovery index: index 鈮，

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