脂溢性脱发与代谢综合征的相关性研究

发布时间：2018-04-22 07:12

  本文选题：脂溢性脱发 + 代谢综合征　； 参考：《广州中医药大学》2016年硕士论文

【摘要】：目的：1.本研究检测不同年龄段脂溢性脱发(AGA)患者的空腹血糖、TG,、TC、HDL-C、 LDL-C、腰围、BMI、血压等代谢综合征(Ms)相关指标,以探讨脂溢性脱发与Ms的相关性。2.本研究观测脂溢性脱发不同脱发等级及中医证型与空腹血糖、TG、TC、 HDL-C、 LDL-C,腰围、BMI、血压等MS相关指标的相关性,以期为临床防治AGA患者发生Ms提供一些思路。方法：本研究共纳入脂溢性脱发患者168例,健康体检者170例。检测两组空腹血糖、TG、TC、 HDL-C、 LDL-C、腰围、BMI、血压等Ms相关指标,并进行统计分析。结果：1.脂溢性脱发患者合并代谢综合征的有12例(7.14%),健康体检者合并代谢综合征的有4例(2.35%),脂溢性脱发患者合并代谢综合征的概率较健康体检者的明显升高,差异具有显著性。2.本研究所纳入168例脂溢性脱发患者中有明确家族史的69例,占41.07%。3.广东地区20-25岁、26-30岁、31-35岁3个年龄段脂溢性脱发患者的空腹Tc、LDL-C水平及异常率均明显高于健康体检者,差异具有显著性。4.广东地区脂溢性脱发患者脱发等级按Hamilton-Norwood scale标准进行分组,其中Ⅱ级有60人,占35.71%,Ⅲ级有57人,占33.93%,Ⅳ级有51人,占30.36%。年龄对TC、LDL-C影响较少或无影响,而脱发等级与TC、LDL-C呈正相关关系,脱发等级越高,发生MS的风险越高。5.广东地区脂溢性脱发患者的中医证型以肝肾不足证为主,占41.67%；而湿热内蕴证及血虚风燥证分别为35.71%、22.62%。不同中医证型脂溢性脱发患者的MS相关指标存在差异,湿热内蕴证脂溢性脱发患者Tc、HDL-C水平及异常率均明显高于肝肾不足证及血虚风燥证,湿热内蕴可能是导致脂溢性脱发患者发生代谢综合征的促发因素之一。结论：1.广东地区脂溢性脱发患者可能容易发生代谢综合征,患者空腹TC、LDL-C的水平及异常率均明显高于相同年龄段的健康体检者。2.广东地区不同脱发等级脂溢性脱发患者MS相关指标存在差异,年龄对TC、LDL-C影响较少或无影响,而脱发等级与TC、LDL-C呈正相关关系,脱发等级越高,发生MS的风险越高。3.广东地区脂溢性脱发患者中医辨证分型比例从高到低依次是肝肾不足证、湿热内蕴证、血虚风燥证。不同中医证型脂溢性脱发患者MS相关指标存在差异,湿热内蕴证脂溢性脱发患者Tc、HDL-C水平及异常率明显高于肝肾不足证及血虚风燥证,湿热内蕴可能是导致脂溢性脱发患者发生代谢综合征的促发因素之一。
[Abstract]:Purpose 1. In order to explore the correlation between seborrheic alopecia and Ms, the study examined the related indexes of fasting blood glucose (TGG), TCU (HDL-C, LDL-C), waist circumference (BMI) and blood pressure (BP) in patients with seborrheic alopecia (AGAA) in different age groups, in order to explore the correlation between seborrheic alopecia and Ms. In this study, we observed the correlation between different grades of seborrheic alopecia and TCM syndromes and MS related indexes such as TGG TC, HDL-C, LDL-C, waist circumference BMIand blood pressure, etc, in order to provide some ideas for clinical prevention and treatment of AGA patients. Methods: 168 patients with seborrheic alopecia and 170 healthy persons were enrolled in this study. Ms related indexes such as TGG, HDL-C, LDL-C, BMI, blood pressure and so on were detected and statistically analyzed in the two groups. The result is 1: 1. There were 12 cases of seborrheic alopecia complicated with metabolic syndrome and 4 cases of healthy check-up with metabolic syndrome. The probability of seborrheic alopecia complicated with metabolic syndrome was significantly higher than that of healthy person (P < 0.05). 69 of 168 seborrheic alopecia patients (41.07%) had a family history. The fasting Tc LDL-C level and abnormal rate of seborrheic alopecia patients aged 20-25 years old from 26 to 30 years old were significantly higher than those of healthy controls (P < 0.05). The hair loss grade of seborrheic alopecia patients in Guangdong area was divided into groups according to Hamilton-Norwood scale standard. Among them, there were 60 cases in grade 鈪，

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