婴儿血管瘤发生与其父母环境因素Logistic回归分析

发布时间：2018-04-22 15:46

  本文选题：婴儿血管瘤 + 环境因素　； 参考：《临床皮肤科杂志》2014年08期

【摘要】：目的:探讨婴儿血管瘤发病的环境危险因素。方法:2010年5月2012年12月,上海交通大学医学院附属新华医院皮肤科门诊收集年龄≤12个月的婴儿血管瘤患者及健康对照各936例。对其父母进行面对面访谈式问卷调查,内容包括孕前1年内和(或)孕期父母的一般情况及可能的环境危险因素。运用Logistic模型对数据进行单因素和多因素回归分析疾病的危险因素,计算比值比和95%可信区间。结果:单因素回归分析筛选出婴儿血管瘤发生的危险因素共9个。多因素回归分析显示父亲职业暴露油漆涂料(OR=2.223,95%CI:1.366~3.620)、汽油柴油(0R=1.719,95%CI:1.096~2.698)、化肥农药(OR=2.511,95%CI:1.546~4.079),和母亲职业暴露化肥农药(OR=2.042,95%CI:1.349~3.094)、皮革塑料粘合剂(OR=3.371,95%CI:2.030~5.596),母亲服用营养滋补品(OR=1.412,95%CI:1.057~1.889)、医师处方保胎药(OR=11.534,95%CI:7.990~16.651),以及父母居室方圆500米内有化工企业和(或)染料印刷企业(OR=2.197,95%CI:1.398~3.455)均是婴儿发生血管瘤的危险因素。结论:婴儿血管瘤的发生与父母孕前1年内和(或)孕期某些环境因素(主要是环境雌激素)的暴露相关。
[Abstract]:Objective: to investigate the environmental risk factors of infantile hemangioma. Methods: 936 cases of infantile hemangioma and 936 healthy controls were collected from Department of Dermatology, Xinhua Hospital affiliated to Shanghai Jiaotong University Medical College in May, 2010. Face-to-face interviews were conducted on their parents, including the general situation and possible environmental risk factors of their parents during 1 year before pregnancy and / or during pregnancy. Logistic model was used to analyze the risk factors of disease by univariate and multivariate regression. The ratio ratio and 95% confidence interval were calculated. Results: nine risk factors of infantile hemangioma were screened by single factor regression analysis. 澶氬洜绱犲洖褰掑垎鏋愭樉绀虹埗浜茶亴涓氭毚闇叉补婕嗘秱鏂，

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