派特灵与微波联合重组人干扰素α-2b乳膏治疗不同亚型HPV感染尖锐湿疣的临床疗效观察

发布时间：2018-04-24 19:16

本文选题：尖锐湿疣 + 人乳头瘤病毒　；参考：《中国艾滋病性病》2017年11期

【摘要】：目的观察派特灵与微波联合重组人干扰素α-2b乳膏治疗不同亚型人乳头瘤病毒(HPV)感染尖锐湿疣的临床效果。方法根据分型结果选取确诊的104例尖锐湿疣患者,采取随机分配的方式,52例患者采取派特灵治疗,52例患者采用微波联合干扰素α-2b乳膏治疗,并分别于治疗前、治疗满1个月及满4个月时复查HPV亚型,观察HPV转阴率,制定疗效标准,观察两组疗效及复发情况。结果派特灵组52例尖锐湿疣患者在治疗满1个月时,复查HPV转阴率为46.2%;治疗满4个月时复查HPV转阴率为86.5%,总有效率为90.4%。微波联合干扰素α-2b乳膏组52例尖锐湿疣患者在治疗满1个月时,复查HPV转阴率为36.5%,治疗满4个月时复查HPV转阴率为78.8%,总有效率为84.6%。派特灵组的总体疗效及对一重感染、二重感染及低危型别感染方面的疗效优于微波联合干扰素α-2b乳膏组(P0.05)。结论派特灵对HPV有较好的清除作用,可以有效地治疗尖锐湿疣,对低危型、一重感染治疗效果尤佳,能减少复发率,可作为治疗尖锐湿疣的新药应用于临床。
[Abstract]:Objective to observe the clinical effect of peterling combined with microwave in the treatment of condyloma acuminatum infected with different subtypes of human papillomavirus (HPV). Methods 104 patients with condyloma acuminatum were selected according to the typing results, 52 patients were treated with peterin and 52 patients were treated with microwave and interferon 伪 -2b cream respectively before treatment. After 1 month and 4 months of treatment, the subtypes of HPV were reexamined, the negative rate of HPV was observed, the standard of curative effect was established, and the curative effect and recurrence of the two groups were observed. Results 52 cases of condyloma acuminatum were treated with Paitelin for one month, the negative rate of HPV was 46.2%, the negative rate of HPV was 86.5% at the end of 4 months, the total effective rate was 90.4%. In the microwave combined with interferon 伪 -2b cream group, 52 patients with condyloma acuminatum turned negative at the end of one month, the negative rate of HPV was 36.5, and the negative rate of HPV was 78.8 at the end of 4 months. The total effective rate was 84.6. The overall curative effect of peterin group was better than that of microwave combined with interferon 伪 -2b cream group in terms of primary infection, double infection and low risk type infection. Conclusion Paterin can effectively treat condyloma acuminatum, especially for low risk type and double infection, which can reduce the recurrence rate and can be used as a new drug for treatment of condyloma acuminatum.
【作者单位】：宁夏医科大学;宁夏医科大学总医院皮肤科;宁夏医科大学总医院检验科;
【基金】：宁夏自然科学基金资助(NZ14138)
【分类号】：R752.53

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