哌拉西林舒巴坦钠联合土茯苓、金银花治疗二期梅毒的疗效分析

发布时间：2018-04-26 23:21

本文选题：哌拉西林舒巴坦钠 + 土茯苓　；参考：《中药材》2015年08期

【摘要】：目的:考察哌拉西林舒巴坦钠联合土茯苓、金银花治疗二期梅毒的疗效及对血清Foxp3、炎症因子和T细胞亚群的影响。方法:收集2010年4月至2013年12月在天津市中医药研究院附属医院及广东省惠州市皮肤病医院收治确诊为二期梅毒的患者109例,按就诊时间,将所有患者随机分为2组,对照组53例,观察组56例,另选择同期健康体检者49例为正常组。结果:治疗前对照组和观察组患者血清各指标差异无统计学意义(P0.05)。治疗后,对照组和观察组患者血清Foxp3 mRNA表达、IL-6、IL-8、TNF-α含量及CD3+、CD4+、CD8+、CD4+/CD8+、NK细胞和MMSE评分均较治疗前显著改善(P0.05),且观察组改善显著优于对照组(P0.05);两组总有效率差异无统计学意义,但观察组痊愈率显著高于对照组(P0.05);观察组复发率显著低于对照组(P0.05)。两组在治疗期间均无明显不良反应。结论:土茯苓与金银花联合应用可通过降低Foxp3、IL-6、IL-8、TNF-α和改善T细胞亚群治疗二期梅毒,并预防复发。
[Abstract]:Objective: to investigate the efficacy of piperacillin sulbactam sodium combined with Poria cocos and honeysuckle in the treatment of secondary syphilis and its effect on serum Foxp3, inflammatory factors and T cell subsets. Methods: from April 2010 to December 2013, 109 patients with secondary syphilis were collected from affiliated Hospital of Tianjin Institute of traditional Chinese Medicine and Huizhou Dermatology Hospital of Guangdong Province. According to the time of treatment, all the patients were randomly divided into two groups. There were 53 cases in the control group, 56 cases in the observation group and 49 cases in the control group. Results: there was no significant difference in serum indexes between control group and observation group before treatment (P 0.05). After treatment, the levels of serum Foxp3 mRNA and the scores of CD3 CD4, CD8, CD4 / CD8, NK cells and MMSE in the control group and the observation group were significantly improved compared with those before the treatment, and the improvement in the observation group was significantly better than that in the control group (P 0.05), the total effective rate of the two groups was not significantly different from that of the control group, and there was no significant difference in the total effective rate between the two groups. But the cure rate in the observation group was significantly higher than that in the control group, and the recurrence rate in the observation group was significantly lower than that in the control group. There were no significant adverse reactions during treatment in both groups. Conclusion: the combination of Poria cocos and Flos Lonicerae can be used to treat secondary syphilis and prevent recurrence by reducing Foxp3 + IL-6 and IL-8 TNF- 伪 and improving T cell subsets.
【作者单位】：天津市中医药研究院附属医院皮肤科;广东省惠州市皮肤病医院;
【分类号】：R759.1

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