5-氨基酸酮戊酸光纤导入红光组织内照射疗法与红蓝光对中重度痤疮的临床疗效的对比研究

发布时间：2018-04-27 07:30

本文选题：痤疮 + 中重度　；参考：《中国地方病防治杂志》2016年05期

【摘要】：目的对比5-氨基酮戊酸(ALA)光纤导入红光组织内照射疗法与红蓝光对中重度痤疮的临床疗效。方法收集我院2013年10月至2015年6月收治的82例中重度痤疮患者,参照抽签法分作对照组和研究组,每组41例,对照组采取红蓝光治疗,研究组采取ALA光纤导入红光组织内照射疗法治疗,比较两组患者治疗后的症状积分、血清TNF-α及IL-8水平、临床疗效。结果治疗后,研究组症状积分(6.85±0.73)分低于对照组(9.49±0.84)分,比较有显著差异(P0.05);研究组血清TNF-α及IL-8水平[(29.34±4.20)ng/L、(36.41±7.23)ng/L]低于对照组[(35.26±4.59)ng/L、(40.28±7.62)ng/L],比较有明显差异(P0.05);研究组总有效率(36/41)87.80%优于对照组的(26/41)63.41%,比较有明显差异(P0.05)。结论中重度痤疮采取ALA光纤导入红光组织内照射疗法治疗的临床疗效显著优于红蓝光治疗,值得推广。
[Abstract]:Objective to compare the clinical effects of 5 aminolevulinic acid (ALAA) optical fiber in red light tissue irradiation and red blue light in the treatment of moderate and severe acne. Methods 82 patients with moderate and severe acne were collected from October 2013 to June 2015 in our hospital. According to the drawing of lots, they were divided into two groups: control group (n = 41) and study group (n = 41). The control group was treated with red and blue light. The patients in the study group were treated with ALA fiber-guided red light tissue irradiation. The symptom scores, serum TNF- 伪 and IL-8 levels and clinical efficacy were compared between the two groups. Results after treatment, the score of symptom score was 6.85 卤0.73 in the study group and 9.49 卤0.84 in the control group. The levels of serum TNF- 伪 and IL-8 in the study group were significantly lower than those in the control group [29.34 卤4.20ng / L ~ 36.41 卤7.23)ng/L] and (35.26 卤4.59ng / L ~ 40.28 卤7.62)ng/L), respectively (P = 0.055.The total effective rate of the study group was higher than that of the control group (P < 0.05). Conclusion the treatment of moderate and severe acne with ALA fiber-guided red light irradiation is more effective than that of red and blue light, and it is worth popularizing.
【作者单位】：四川省医学科学院四川省人民医院皮肤科;
【基金】：四川省科研院所科技成果转化资金项目(编号:14010134)
【分类号】：R758.733

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