积雪苷外敷并口服联合曲尼司特治疗外伤瘢痕增生的临床观察

发布时间：2018-04-30 07:54

本文选题：积雪苷 + 外敷　；参考：《中国药房》2017年02期

【摘要】：目的:观察积雪苷外敷并口服联合曲尼司特治疗外伤瘢痕增生的临床疗效及安全性。方法:选取2014年12月-2015年12月邢台市人民医院皮肤科收治的外伤瘢痕增生患者126例,根据用药方案的不同将其分为对照组和观察组,各63例。两组患者均给予曲尼司特胶囊,每次0.1 g,tid;观察组患者在此基础上外敷积雪苷霜软膏适量,每天3~4次,并加服积雪苷片,每次12~24 mg,tid。两组患者均治疗8周。比较两组患者临床疗效、1年内复发率、平均用药时间、症状消失时间、治疗满意度,以及不良反应发生情况。结果:治疗后,观察组患者治疗总有效率(93.65%)明显高于对照组(77.78%),1年内复发率(4.76%)明显低于对照组(15.87%),差异均有统计学意义(P0.05);观察组患者平均用药时间和症状消失时间明显短于对照组,治疗满意度明显高于对照组,差异均有统计学意义(P0.05);观察组患者不良反应发生率(6.35%)明显低于对照组(17.46%),差异有统计学意义(P0.05)。结论:积雪苷外敷并口服联合曲尼司特治疗外伤瘢痕增生疗效显著,可降低患者瘢痕增生复发率,缩短其用药时间和症状消失时间,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of topical application of snow glycoside combined with tranilast in the treatment of traumatic scar hyperplasia. Methods: 126 patients with traumatic scar hyperplasia admitted in Department of Dermatology of Xingtai people's Hospital from December 2014 to December 2015 were divided into control group (n = 63) and observation group (n = 63). The patients in both groups were given tranilast capsule 0.1 g / d each time, and the patients in the observation group were treated with a proper amount of snow glycoside cream on this basis, 3 times a day, 4 times a day, and added with snow glycoside tablet, 124mg / d each time. Both groups were treated for 8 weeks. The clinical efficacy, recurrence rate, average time of medication, time of symptom disappearance, treatment satisfaction and adverse reaction were compared between the two groups. Results: after treatment, the total effective rate of treatment in the observation group was significantly higher than that in the control group (77.78) and the recurrence rate within one year was 4.76) significantly lower than that in the control group (15.87g / kg), the difference was statistically significant (P 0.05), the average time of medication and symptom disappearance in the observation group was significantly shorter than that in the control group. The treatment satisfaction was significantly higher than that in the control group (P 0.05), and the incidence of adverse reactions in the observation group was 6.35%, which was significantly lower than that in the control group (P 0.05). Conclusion: the treatment of scar hyperplasia by external application of snow glycoside and oral combined with tranilast is effective, which can reduce the recurrence rate of scar hyperplasia, shorten the time of medication and the time of symptom disappearance, and the safety is good.
【作者单位】：邢台市人民医院皮肤科;邢台市人民医院中医外科;河北医科大学第四医院皮肤科;
【基金】：河北省卫生厅科研基金项目(No.20150174)
【分类号】：R751.05

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