皮肤的纳米生物摩擦学行为研究

发布时间：2018-05-02 23:51

本文选题：皮肤 + 护肤霜　；参考：《中国矿业大学》2010年博士论文

【摘要】： 皮肤宏观摩擦学研究有效的模拟了现实生活中皮肤与各种物体表面的接触,有重要的现实意义,而皮肤纳米摩擦学研究在纳米尺度上深入研究皮肤的表面微观组织结构,以及皮肤与相对运动表面在接触界面上分子间的相互作用,两者相互结合,有助于建立完善的皮肤摩擦学理论。同时研究表皮-护肤霜分子之间的相互作用,对于开发高效的护肤品具有重要意义。本文以大鼠表皮、人造皮肤和人体皮肤为研究对象,使用原子力显微镜(AFM)和纳米压痕仪研究了大鼠表皮(简称表皮)和护肤霜涂覆表皮(简称涂覆表皮)的纳米力学性能、摩擦性能和摩擦电性能,研究了人造皮肤的纳米摩擦性能,使用往复摩擦试验机研究了宏观尺度下表皮和涂覆表皮的摩擦性能,使用UMT-2多功能摩擦磨损试验机研究了人手皮肤和护手霜涂覆人手皮肤的摩擦性能、人体皮肤和纺织品之间的摩擦性能,主要结论如下: 大鼠表皮的纳米力学性能试验研究显示,表皮和涂覆表皮的表面划痕深度随着载荷的增加而增大;当载荷小于15μN时,涂覆表皮具有较好的抗擦伤性;护肤霜可以有效的软化皮肤,增加皮肤的弹性和延展性,降低皮肤角质层碎片的产生。大鼠表皮的纳米摩擦学性能研究显示,护肤霜能够降低表皮的粗糙度并且提高表皮的亲水性;表皮的摩擦系数和粘着力随着膜厚、速度和载荷的变化而变化;环境湿度和温度显著影响表皮的摩擦系数和粘着力;由于表面膜厚的变化,表皮和涂覆表皮的摩擦系数和粘着力随着扫描周期的变化而变化。大鼠表皮的纳米摩擦电特性研究显示,环境中的水分和护肤霜可以有效的消除表皮的静电荷。皮肤上的摩擦静电荷通过与周围空气的接触而衰减;表皮在摩擦过程中容易产生静电,而护肤品能够很好的抑制摩擦电荷的产生;当采用宏观尺度方法摩擦表皮时,绝对电势的变化大于纳米尺度摩擦方法;表皮和涂覆表皮的表面绝对电势的变化量随着速度、载荷和摩擦时间的增大而增大。护肤霜对大鼠表皮纳米摩擦学性能的影响研究显示,纯羊毛脂和纯凡士林具有较好的持久性,质地粘着油腻。无油护肤霜和普通护肤霜的持久性相对较低,质地润滑。水合甘油的持久性最差,质地润滑;高动态粘度的护肤霜的持久性较好,同时会使表皮产生高的摩擦系数。环境湿度对五种涂覆表皮的粘着和力学性能影响的研究显示,环境湿度影响表皮的表面膜厚、粘着力和弹性模量。人造皮肤的纳米摩擦学性能研究显示,人造皮肤具有和大鼠表皮相似的表面性能和摩擦性能,是大鼠表皮的适当替代物;由于人造皮肤-2的硬度和大鼠表皮相似,人造皮肤-2比人造皮肤-1更适合作为大鼠表皮的替代物使用;当涂覆护肤品后,人造皮肤显示出和大鼠表皮相似的表面、摩擦和力学性能变化,因此在护肤品研究中适合作为大鼠表皮的替代物使用。大鼠表皮的宏观摩擦学性能研究显示,表皮和涂覆表皮的摩擦学性能对尺度有依赖性。宏观尺度下测得皮肤摩擦系数大于纳米尺度下测得的。不同研究尺度下,护肤霜膜厚、速度和载荷对表皮和涂覆表皮摩擦性质的影响有一定差异,表皮和涂覆表皮的磨损性能有一定的差异。人体皮肤的宏观摩擦性能试验研究显示,皮肤湿度和温度显著影响皮肤的摩擦性能;人体手部皮肤的摩擦性能研究表明,人体手部四个部位皮肤的摩擦系数的从高到低依次为指纹,手掌,手背和指甲;护手霜涂覆皮肤的摩擦性能研究表明,甘油护手霜的润肤效果最明显,凡士林护手霜和普通护手霜的润肤效果相近。凡士林护手霜的保持效果最佳,甘油护手霜和普通护手霜的保持效果相近;皮肤-纺织品的摩擦性能研究表明,四种纺织品的摩擦系数由高到低分别为毛呢,皮革,丝绸和棉布。
[Abstract]:The study of skin macrotribology effectively simulates the contact between the skin and the surface of various objects in real life, and it has important practical significance. The skin nano tribological study studies the microstructure of the skin surface and the interaction between the skin and the relative motion surface at the contact interface. Combining with each other helps to establish a perfect theory of skin tribology. At the same time, it is of great significance to study the interaction between skin cream molecules and to develop efficient skin care products.
In this paper, the nanomechanical properties, friction properties and friction electrical properties of rat epidermis (abbreviated epidermis) and skin cream coated epidermis were studied by atomic force microscope (AFM) and nano indentation instrument, and the friction properties of the artificial skin were studied. The friction test machine was used to study the friction properties of the epidermis and the coated epidermis on the macro scale. The friction performance of human hand skin and hand cream coated hand skin and the friction properties between human skin and textiles were studied by the UMT-2 multi-function friction and wear tester. The main conclusions are as follows:
The experimental study on the nanomechanical properties of the rat epidermis shows that the surface scratch depth of the epidermis and the coated epidermis increases with the increase of the load. When the load is less than 15 mu N, the coating epidermis has better abrasion resistance; the skin cream can effectively soften the skin, increase the elasticity and ductility of the skin, and reduce the production of the cuticle fragments.
The study of the nano tribological properties of the rat epidermis shows that the skin cream can reduce the roughness of the epidermis and improve the hydrophilicity of the epidermis. The friction coefficient and adhesion of the epidermis vary with the change of the thickness of the membrane, the velocity and the load, and the environmental humidity and temperature influence the friction coefficient and adhesion of the epidermis. The friction coefficient and adhesive force of skin and coated skin change with the change of scanning period.
The study of the nano friction electrical properties of the rat epidermis shows that the water and skin cream in the environment can effectively eliminate the static charge of the epidermis. The friction static charge on the skin attenuates through contact with the surrounding air; the epidermis can easily produce static electricity during the friction process, and the skin care product can inhibit the generation of the friction charge well; when adopting the macro When the scale method friction the epidermis, the change of absolute potential is greater than that of the nano scale friction method, and the change of surface absolute potential of the epidermis and the coated epidermis increases with the increase of velocity, load and friction time.
The effect of skin cream on the skin nano tribological properties of rats showed that pure lanolin and pure Vaseline had better durability, the texture was greasy, the durability of oil free skin cream and ordinary skin cream was relatively low, the texture was lubricated. The durability of hydrated glycerol was the worst, the texture was lubricated, and the persistence of high dynamic viscosity cream was better. The effect of ambient humidity on the adhesion and mechanical properties of the five coated epidermis shows that the ambient humidity affects the surface film thickness, adhesion and modulus of elasticity of the epidermis.
The study of nano tribological properties of artificial skin shows that artificial skin has similar surface and frictional properties with rat epidermis, which is the appropriate substitute for rat epidermis. Because the hardness of artificial skin -2 is similar to that of rat skin, artificial skin -2 is more suitable to be used as a substitute for rat epidermis than that of artificial skin -1; when coating skin care products, the artificial skin is used as a skin care product. After that, the artificial skin shows the surface, friction and mechanical properties of the rat's epidermis, so it is suitable to be used as a substitute for the skin of the rat in the skin care research.
The study of the macro tribological properties of the epidermis of rats showed that the tribological properties of the epidermis and the coated epidermis were dependent on the scale. The skin friction coefficient measured at the macro scale was greater than that measured in the nanoscale. The effect of skin cream thickness, velocity and load on the skin and the coating skin friction properties under different scale were different. The wear properties of the skin and the coating are different.
The experimental study on the macro friction performance of human skin showed that the skin humidity and temperature significantly affected the skin's friction performance, and the friction performance of the human hand skin showed that the friction coefficient of the skin of the four parts of the human hand from high to low was the fingerprint, the palm, the hand back and the nail, and the friction performance of the hand cream coated skin. The moisturizing effect of glycerol hand cream is the most obvious, Vaseline hand cream and ordinary hand cream are similar. The Vaseline hand cream is the best, the glycerol hand cream and the ordinary hand cream keep the same effect; the friction properties of the skin textiles show that the friction coefficient of the four kinds of textiles is from high to low, respectively. Leather, silk and cotton.

【学位授予单位】：中国矿业大学
【学位级别】：博士
【学位授予年份】：2010
【分类号】：R751

【引证文献】