甘肃省敦煌地区普通人群卡波肉瘤相关疱疹病毒感染的血清学分析

发布时间：2018-05-06 08:37

  本文选题：卡波肉瘤相关疱疹病毒 + 血清阳性率　； 参考：《安徽医科大学学报》2017年05期

【摘要】：目的研究卡波肉瘤相关疱疹病毒(KSHV)在甘肃敦煌地区普通人群中的血清阳性率,并分析KSHV感染的危险因素。方法随机收集1 000例敦煌地区普通人群血清,以KSHV 3个基因片段orf65、orf73、orf k8.1编码蛋白为抗原,间接ELISA检测样本中KSHV抗体,SPSS软件分析危险因素。结果 1 000份血清中,KSHV抗体总阳性率为19%,男性阳性率(22.9%)高于女性(16.6%)(P=0.016);KSHV感染与梅毒螺旋体(P=0.004)和丙肝病毒(P=0.027)感染间有相关性,而与年龄、乙肝五项无关。多因素Logistic回归分析显示梅毒螺旋体感染的OR(95%CI)为10.142(1.920~53.577)。结论甘肃敦煌地区普通人群中KSHV的感染率较高,且与性别有关;梅毒螺旋体感染是该地区KSHV感染最重要的独立危险因素。
[Abstract]:Objective to study the seropositive rate of kaposarcoma associated herpesvirus (KSHV) in the general population of Dunhuang, Gansu, and to analyze the risk factors of KSHV infection. Methods Serum samples of 1 000 general population in Dunhuang area were randomly collected. The three KSHV gene fragments orf65 or f73 orf k8.1 were used as antigen. Indirect ELISA was used to detect the KSHV antibody in the samples and the risk factors were analyzed by SPSS software. Results the total positive rate of KSHV antibody was 19 in 1 000 sera, and the positive rate of KSHV in male was 22. 9%) higher than that in female. There was a correlation between KSHV infection and the infection of Treponema pallidum P0. 004) and hepatitis C virus (P0. 027) infection. Multivariate Logistic regression analysis showed that the OR95 CI of Treponema pallidum infection was 10.142 (1.920) and 53.577 (P < 0.05). Conclusion the infection rate of KSHV in the general population in Dunhuang area of Gansu Province is high and related to sex. Treponema pallidum infection is the most important independent risk factor for KSHV infection in this area.
【作者单位】： 安徽医科大学微生物学教研室;
【基金】：国家自然科学基金(编号:81271837) 安徽高校省级自然科学研究项目(编号:KJ2012A161) 安徽医科大学博士科研经费资助项目(编号:XJ200914)
【分类号】：R752.1
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本文编号：1851575