300例住院药疹患者回顾性临床分析

发布时间：2018-05-06 11:25

本文选题：药疹 + 致病药物　；参考：《新疆医科大学》2012年硕士论文

【摘要】：目的：探讨临床上药疹的类型及其相关致敏药物，为今后药疹的诊治工作提供参考。方法:本文对2007年1月至2010年12月4年间我科收治的确诊药疹患者300例进行回顾性分析。结果：300例患者中有82.7％可明确为一种致敏药物。由青霉素类引起的药疹共有37例，解热镇痛药引起的药疹共有43例。重症药疹共24例，其中由抗癫痫药及解热镇痛药引起的分别有9例及5例。抗癫痫药引起的药疹中重症药疹占37.5％，治疗所需的糖皮质激素控制剂量多为80-120mg/d，病程较长。结论:抗生素类、中药及中成药类及解热镇痛类药物是引起药疹最常见的药物。引起重症药疹的药物主要为抗癫痫药及解热镇痛药。糖皮质激素治疗与并发症的治疗是重症药疹的关键。
[Abstract]:Objective: to explore the clinical types of drug eruption and its related sensitizers, and to provide reference for the diagnosis and treatment of drug eruption in the future. Methods: from January 2007 to December 2010, 300 patients with drug eruption were retrospectively analyzed. Results 82.7% of the 300 patients were identified as an sensitizer. There were 37 cases of drug rash caused by penicillin and 43 cases of drug eruption caused by antipyretic and analgesics. There were 24 cases of severe drug eruption, of which 9 cases were caused by antiepileptic drugs and 5 cases by antipyretic analgesics. The drug rash caused by antiepileptic drugs accounted for 37.5%. The controlled dose of glucocorticoid for treatment was 80-120 mg / d and the course of disease was longer. Conclusion: antibiotics, traditional Chinese medicine, traditional Chinese medicine and antipyretic and analgesic drugs are the most common drugs to cause drug rash. The main drugs causing severe drug eruption are antiepileptic and antipyretic analgesics. Glucocorticoid therapy and complications are the key to severe drug eruption.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.25

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