寻常型银屑病患者血清瘦素及脂联素水平的研究

发布时间：2018-05-08 05:31

本文选题：瘦素 + 瘦素受体　；参考：《中国医科大学》2010年硕士论文

【摘要】： 目的银屑病是一种常见的慢性炎症性皮肤病,其确切病因尚未完全清楚。新近研究表明,银屑病和代谢综合征有关：伴有代谢综合征的银屑病患者较不患代谢综合征的患者年龄更大,病程更长。代谢综合征是以胰岛素抵抗为核心,遗传异质性和环境因素导致的一系列心血管疾病高危因素的聚集状态。肥胖是其发生的源头。脂肪组织可以分泌多种生物活性物质,这些物质被称为脂肪因子。瘦素(leptin)和脂联素(adiponectin)是近年来发现的特异性脂肪因子,是体内营养状态与神经内分泌-免疫系统之间相互影响、相互作用的重要中介。瘦素主要通过与存在于多种组织中的多种形式的受体(OB-R)结合,调节T细胞的功能及其细胞因子的产生,影响自身免疫性疾病的发生与发展。脂联素是脂肪组织表达最丰富的激素,不仅与肥胖及胰岛素抵抗有着密切的关系,而且具有重要的抗炎及血管保护作用。已有研究表明瘦素与多种皮肤疾病相关,如白塞综合征、系统性红斑狼疮、硬皮病、天疱疮等。为了探讨这两种脂肪因子与寻常型银屑病的相关性,我们测定了寻常型银屑病患者血清瘦素、可溶性瘦素受体和脂联素的水平,分析其在寻常型银屑病中的变化及意义。方法采用夹心法酶联免疫吸附技术检测48例寻常型银屑病(PV)患者及30例正常对照组血清瘦素、可溶性瘦素受体及脂联素的水平。计量资料以均数±标准差(x±s)表示,应用SPSS13.0软件系统进行t检验及Pearson相关分析,p0.05有统计学意义。结果与正常对照组相比,PV患者血清可溶性瘦素受体及脂联素水平明显降低,差异有统计学意义(p0.01)；血清瘦素水平可见显著的性别差异,女性较男性瘦素水平明显升高,差异有统计学意义(p0.01)；男性患者较男性正常对照脂联素水平明显降低,差异有统计学意义(p0.01)；女性患者较女性正常对照可溶性瘦素受体水平明显降低,差异有统计学意义(p0.05)；BMI(体质指数)25的患者较正常对照可溶性瘦素受体及脂联素水平明显降低,差异有统计学意义(p0.01)。患者病情.严重程度(PASI)与BMI及瘦素／脂联素的比值呈正相关(p0.01,r=0.44；p0.01,r=0.40)。结论寻常型银屑病中存在瘦素、瘦素受体和脂联素水平的异常,瘦素及脂联素水平的变化可能在银屑病发生、发展过程中起作用。
[Abstract]:Purpose Psoriasis is a common chronic inflammatory dermatosis whose exact etiology is not fully understood. Recent studies have shown that psoriasis is associated with metabolic syndrome: psoriatic patients with metabolic syndrome are older and longer in duration than those without metabolic syndrome. Metabolic syndrome is the aggregation of a series of high risk factors of cardiovascular disease caused by genetic heterogeneity and environmental factors with insulin resistance as the core. Obesity is the source of its occurrence. Adipose tissue can secrete a variety of bioactive substances, known as fat factors. Leptin (leptinin) and adiponectin (adiponectin) are specific fat factors found in recent years. They are important mediators of the interaction between nutritional status and neuroendocrine immune system in vivo. Leptin regulates the function of T cells and the production of cytokines by binding to various forms of receptor OB-Rin in various tissues and affects the occurrence and development of autoimmune diseases. Adiponectin is the most abundant hormone in adipose tissue. Adiponectin is not only closely related to obesity and insulin resistance, but also has important anti-inflammatory and vascular protective effects. Leptin has been linked to many skin diseases, such as Behcet's syndrome, systemic lupus erythematosus, scleroderma, pemphigus, etc. In order to investigate the relationship between these two kinds of fat factors and psoriasis vulgaris, we measured the serum leptin, soluble leptin receptor and adiponectin levels in patients with psoriasis vulgaris, and analyzed their changes and significance in psoriasis vulgaris. Method The levels of serum leptin, soluble leptin receptor and adiponectin in 48 patients with psoriasis vulgaris PVV and 30 normal controls were detected by enzyme-linked immunosorbent assay (Elisa). The measurement data were expressed as mean 卤standard deviation (x 卤s). The SPSS13.0 software system was used for t test and Pearson correlation analysis (p0.05). Result The serum levels of soluble leptin receptor and adiponectin in PV patients were significantly lower than those in normal controls (P 0.01), and the serum leptin levels in women were significantly higher than those in men. The level of adiponectin in male patients was significantly lower than that in normal controls (P 0.01), and the level of soluble leptin receptor in female patients was significantly lower than that in normal controls. The levels of soluble leptin receptor and adiponectin in patients with BMI 25 were significantly lower than those in normal controls (P 0.01). The patient's condition. The severity of PASI was positively correlated with BMI and the ratio of leptin to adiponectin. Conclusion There are abnormal levels of leptin, leptin receptor and adiponectin in psoriasis vulgaris. The changes of leptin and adiponectin levels may play an important role in the pathogenesis and development of psoriasis.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.63

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