2011-2013年广州地区无偿献血者梅毒筛查与确认结果分析

发布时间：2018-05-08 18:16

本文选题：梅毒 + 无偿献血者　；参考：《广东医学》2015年04期

【摘要】：目的了解广州地区无偿献血者梅毒感染情况,探讨血液筛查中梅毒检测阳性标本采用梅毒螺旋体明胶凝集试验(TPPA)确认的意义。方法统计分析2011—2013年广州地区无偿献血梅毒感染情况;采用2种国产梅毒抗体ELISA试剂A、B对本中心无偿献血者标本进行筛查,用TPPA法对筛查阳性标本进行确认,比较分析2012年A、B试剂梅毒抗体初筛和TPPA的阳性符合率。结果 2011—2013年广州地区无偿献血843 699例,筛查梅毒阳性标本4 781例,TPPA确认阳性3 156例,梅毒感染率为0.37%。不同献血来源和职业献血人群梅毒阳性率差异有统计学意义(醊2=984.5,P0.05),其中街头流动人员献血人群梅毒阳性率最高(0.65%),大中专院校学生献血人群最低(0.06%)。18~29岁年龄段献血员梅毒阳性率为0.17%,阳性率随年龄段升高而升高。男性阳性率高于女性;2012年初筛阳性标本1 610例,TPPA确认阳性1 099例,阳性符合率为68.26%。A、B试剂单检筛查阳性与TPPA确认结果的阳性符合率分别为86.13%、73.36%,双试剂联检阳性符合率为94.47%。结论广州地区无偿献血者中,梅毒抗体阳性人群在职业来源、年龄、性别分布均不同,这对日后招募低危献血人群有一定指导作用;对初筛阳性标本进行TPPA的确证是非常必要的,为梅毒阳性献血者的检测结果告知提供更准确依据。
[Abstract]:Objective to understand the situation of syphilis infection in non paid blood donors in Guangzhou, and to explore the significance of syphilis gelatin agglutination test (TPPA) for positive specimens of syphilis detection in blood screening. Methods statistics and analysis were carried out in Guangzhou area from 2011 to 2013, and 2 kinds of domestic syphilis antibody ELISA reagent A and B were used for the non compensation of this center. The specimen of blood donors was screened and the positive specimens were confirmed by TPPA method. The positive rate of A, B and TPPA in 2012 was compared and analyzed. Results from 2011 to 2013, there were 843699 cases of free blood donation in Guangzhou area, 4781 cases of syphilis positive specimens were screened, 3156 cases were confirmed by TPPA, and the rate of syphilis infection was 0.37%. different blood donation. The positive rate of syphilis (2=984.5, P0.05) was the highest (0.65%), and the lowest (0.06%) blood donors in the college were the lowest (0.06%) the positive rate of syphilis was 0.17% in the age group of.18~29 years old, the positive rate increased with the age. The male positive rate was high. At the beginning of 2012, 1610 cases were screened positive specimens, 1099 cases were confirmed positive by TPPA, the positive coincidence rate was 68.26%.A, the positive coincidence rate of B reagent screening positive and TPPA confirmed results was 86.13% and 73.36% respectively. The coincidence rate of double reagent combined test was 94.47%. conclusion in Guangzhou area free blood donors, the syphilis antibody positive population was in the occupational source, Age and gender distribution are all different, which has a certain guiding role in the recruitment of low risk blood donors in the future; it is necessary to confirm the TPPA of the positive specimens for the screening of early screening, and provide more accurate basis for the detection results of syphilis positive donors.

【作者单位】：广州血液中心检验科;
【基金】：广州市医药卫生科技项目(编号:20141A010061,2014A031110001)
【分类号】：R446.6;R759.1

【参考文献】