疱疹样天疱疮13例临床分析

发布时间：2018-05-15 19:54

本文选题：疱疹样天疱疮 + 诊断　；参考：《临床皮肤科杂志》2017年07期

【摘要】：目的:探讨疱疹样天疱疮的临床表现、实验室检查和治疗特点。方法:对13例疱疹样天疱疮患者的临床资料进行回顾性分析。结果:13例患者中男女比例为1.6∶1,平均发病年龄(71±12)岁。大多数患者皮疹主要发生于躯干和四肢,头面部也可累及,多无口腔黏膜累及,临床以环状红斑及紧张性水疱为特点,伴剧烈瘙痒。皮损组织病理表现为表皮内水疱及嗜酸性粒细胞海绵形成。直接免疫荧光显示棘细胞间IgG和(或)C3沉积。糖皮质激素是治疗疱疹样天疱疮的主要药物,重型患者糖皮质激素初始量、最大控制量及累积剂量均高于轻型患者。结论:疱疹样天疱疮是一种有特殊临床表现及组织病理特点的自身免疫性大疱性皮病,多数患者经糖皮质激素治疗病情控制较好。
[Abstract]:Objective: to investigate the clinical manifestation, laboratory examination and treatment of herpes pemphigus. Methods: the clinical data of 13 patients with herpes pemphigus were retrospectively analyzed. Results the ratio of male to female was 1.6: 1, and the mean age of onset was 71 卤12 years. Most patients with rash mainly occurred in the trunk and limbs, the head and face can also be involved, most of the oral mucosal involvement, clinical characteristics of annular erythema and tense blister, with severe pruritus. The pathological features of the lesions were intraepidermal blister and eosinophil sponge formation. Direct immunofluorescence showed the deposition of IgG and / or C 3 in the intercellular spine. Glucocorticoid is the main drug in the treatment of herpetic pemphigus. The initial dose of glucocorticoid, the maximum controlled dose and the cumulative dose of glucocorticoid in severe patients are higher than those in mild patients. Conclusion: herpetic pemphigus is an autoimmune bullous dermatosis with special clinical manifestations and histopathological features. Most patients are well controlled by glucocorticoid therapy.
【作者单位】：上海市皮肤病医院;同济大学附属第十人民医院皮肤科;
【基金】：国家自然科学基金资助(81301356) 上海市自然科学基金(13ZR1432200)资助项目上海市科委引导项目基金(134119b0700)资助项目
【分类号】：R758.66

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