共聚焦激光扫描显微镜在表皮增生性疾病诊断和评估治疗疗效的应用

发布时间：2018-05-16 06:00

本文选题：共聚焦激光扫描显微镜 + 脂溢性角化病　；参考：《天津医科大学》2010年硕士论文

【摘要】： 目的： 1.通过共聚焦激光扫描显微镜采集脂溢性角化病和扁平疣图像,探讨脂溢性角化病和扁平疣的CLSM图像特征。为临床对脂溢性角化病和扁平疣影像学诊断提供可靠依据。 2.利用CLSM评估他扎罗汀凝胶联合NB-UVB治疗斑块型银屑病的治疗效果。方法： 1.通过对经组织病理学确诊的脂溢性角化病和扁平疣的图像分别进行分析,归纳各自相应的特异性诊断指标,并在盲态下采用回顾性分析方法分别对所有图像进行判读,评价CLSM诊断的特异性和敏感性。同时对脂溢性角化病和扁平疣患者CLSM诊断准确率与病理诊断的准确率相比较。 2.利用CLSM分别检测PIS评分、表皮厚度和迂曲毛细血管治疗前后数量变化,评估联合他扎罗汀凝胶和NB-UVB治疗斑块型银屑病是否优于单一NB-UVB治疗结果： 1.脂溢性角化病和扁平疣的CLSM图像特征和病理图像具有较高的一致性,经卡方检验证实：CLSM脂溢性角化病特异性指标为“脑回状”结构、棘层肥厚、角囊肿。扁平疣的特征性指标为“花团状”结构和空泡细胞。CLSM诊断脂溢性角化病灵敏度为100%,特异度为87.5%,CLSM对扁平疣的诊断灵敏度为89.7%,特异度为90.9%。 2..联合他扎罗汀NB-UVB和单一NB-UVB治疗斑块型银屑病均有效,前者的PIS评分和表皮厚度减少量均优于后者。结论： 1.CLSM对脂溢性角化病和扁平疣诊断和鉴别诊断具有较高的灵敏性和特异性。 2.联合他扎罗汀凝胶和NB-UVB治疗斑块型银屑病疗效优于单一NB-UVB治疗。
[Abstract]:Objective: 1. The images of seborrheic keratosis and verruca plana were collected by confocal laser scanning microscope and the CLSM features of seborrheic keratosis and verruca plana were studied. To provide reliable basis for clinical imaging diagnosis of seborrheic keratosis and verruca plana. 2. CLSM was used to evaluate the efficacy of tacarotene gel combined with NB-UVB in the treatment of plaque psoriasis. Methods: 1. The images of seborrheic keratosis and verruca plana diagnosed by histopathology were analyzed, and their respective specific diagnostic indexes were summarized. To evaluate the specificity and sensitivity of CLSM diagnosis. The diagnostic accuracy of CLSM in seborrheic keratosis and verruca plana was compared with that of pathology. 2. CLSM was used to measure the PIS score, the thickness of epidermis and the quantity of convoluted capillaries before and after treatment. To evaluate whether the combination of tazarotene gel and NB-UVB in the treatment of plaque psoriasis was superior to that of NB-UVB alone. Results: 1. The CLSM images of seborrheic keratosis and verruca plana were consistent with pathological images. Chi-square test confirmed that the specific index of seborrheic keratosis was "gyrus" structure, hypertrophy of spinous layer and horn cyst. The characteristic indexes of flat warts are "floral mass" structure and vacuolar cell. CLSM has a sensitivity of 100 for seborrheic keratosis, a specificity of 87.5 and a sensitivity of 89.7 and a specificity of 90.9 for flat warts. 2.. Tazarotene NB-UVB and NB-UVB were effective in the treatment of plaque psoriasis. The PIS score and the decrease of epidermal thickness in the former were better than those in the latter. Conclusion: 1.CLSM has high sensitivity and specificity in the diagnosis and differential diagnosis of seborrheic keratosis and verruca plana. 2. Combination of tazarotene gel and NB-UVB in the treatment of plaque psoriasis is superior to NB-UVB alone.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R758.63

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