毛囊中磺基转移酶活性与局部外用米诺地尔治疗雄激素性秃发疗效相关性研究

发布时间：2018-05-17 01:40

本文选题：磺基转移酶 + 米诺地尔　；参考：《临床皮肤科杂志》2017年06期

【摘要】：目的:用生物标志物预测雄激素性秃发(AGA)患者的疗效。方法:307例AGA患者在脱发边缘区拔取生长期毛发,测量磺基转移酶(SULT 1A1)活性[用吸光度(A)值表示],并询问患者年龄、脱发家族史及体重指数(BMI)。予以2%米诺地尔外用,每日2次,每次1 mL,连续治疗6个月。在基线、治疗6个月时进行全局照相评估,根据患者治疗前后脱发面积和程度的变化判断疗效,将患者分为3组,无效组为病情未控制,脱发继续加重;控制组为病情得到控制;改善组为毛发有再生。结果:治疗6个月后,每例患者测量4根毛发时,改善组与控制组、无效组之间A值差异有统计学意义,控制组与无效组之间A值差异无统计学意义(P_(10)=0.000,P_(1-1)=0.028,P_(0-1)=0.702);每例患者测量8根毛发时,改善组与控制组、无效组之间A值差异有统计学意义,控制组与无效组之间A值差异无统计学意义(P_(10)=0.000,P_(1-1)=0.021,P_(0-1)=0.775)。不同疗效积分之间的A值差异无统计学意义(P0.05)。A值与性别、年龄、脱发家族史、BMI、就诊时脱发严重程度和拔取毛发的部位无相关性。结论:检测SULT 1A1活性可以预测米诺地尔的疗效,4根毛发的敏感性为83%,特异性为82.6%;8根毛发的敏感性为83%,特异性为87%。
[Abstract]:Objective: to predict the effect of androgen alopecia (AGA) by biomarkers. Methods three hundred and thirty seven AGA patients were selected from the marginal area of alopecia and the activity of sulfotransferase (SULT1A1) was measured. The age, family history of alopecia and body mass index (BMI) were asked. 2% minoxidil, 2 times a day, 1 mL per day, for 6 months. At baseline, after 6 months of treatment, the patients were assessed by global radiography. According to the changes of the area and degree of alopecia before and after treatment, the patients were divided into 3 groups. The disease was controlled in the control group and hair regeneration was found in the improvement group. Results: after 6 months of treatment, there was a significant difference in A value between the improvement group and the control group, as well as between the ineffective group and the control group, when each patient measured 4 hairs. There was no significant difference in A value between the control group and the ineffective group. There was no significant difference in A value between the control group and the control group. There was no significant difference in A value between the control group and the ineffective group. There was no significant difference in A value between different curative effect scores. There was no correlation between A value and sex, age, family history of alopecia and BMI.There was no correlation between the severity of alopecia and the position of hair extraction. Conclusion: detection of SULT 1A1 activity can predict the curative effect of minodil. The sensitivity of 4 hairs is 83, the specificity is 82. 6 and the sensitivity of 8 hairs is 83. 3 and the specificity is 87.
【作者单位】：南京医科大学第一附属医院皮肤性病科;
【分类号】：R758.71

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