雷公藤多苷对寻常性银屑病患者血清中白细胞介素-6、17及23水平的影响

发布时间：2018-05-18 21:23

本文选题：银屑病 + 寻常性　；参考：《临床皮肤科杂志》2017年12期

【摘要】：目的:观察雷公藤多苷治疗寻常性银屑病的疗效,并检测其对患者血清中白细胞介素(IL)-6、IL-17及IL-23水平的影响,探讨雷公藤多苷治疗寻常性银屑病的作用机制。方法:采用酶联免疫吸附试验(ELISA)法检测40例寻常性银屑病患者经雷公藤多苷治疗前后血清中IL-6、IL-17及IL-23水平变化。结果:雷公藤多苷治疗寻常性银屑病8周后银屑病皮损面积及严重度指数(PASI)评分显著下降(P0.01)。患者血清中IL-6、IL-17及IL-23水平治疗前分别为(184.16±26.19)ng/L、(7.43±2.02)ng/L和(1622.44±254.56)ng/L,治疗后分别为(136.03±16.19)ng/L、(3.07±0.67)ng/L和(824.72±141.54)ng/L,治疗前后比较,差异有统计学意义(P均0.01),IL-17、IL-23与PASI评分呈正相关。结论:雷公藤多苷治疗寻常性银屑病疗效显著,可能通过调节Th17细胞降低血清中IL-6、IL-17及IL-23的水平发挥作用。
[Abstract]:Aim: to observe the therapeutic effect of tripterygium wilfordii polyglycoside on psoriasis vulgaris, and to detect the effect of tripterygium wilfordii polyglycoside on serum IL-17 and IL-23 levels in patients with psoriasis vulgaris, and to explore the mechanism of tripterygium wilfordii polyglycoside in treating psoriasis vulgaris. Methods: 40 patients with psoriasis vulgaris were treated with Tripterygium wilfordii polyglycoside and the levels of IL-17 and IL-23 in serum were detected by enzyme linked immunosorbent assay (Elisa). Results: after 8 weeks treatment of psoriasis vulgaris with tripterygium wilfordii, the area and severity index (PASI) of psoriasis decreased significantly (P 0.01). The serum levels of IL-6, IL-17 and IL-23 were 184.16 卤26.19 ng / L 7.43 卤2.02)ng/L and 1622.44 卤254.56 ng / L before treatment, and 136.03 卤16.19 ng / L, 3.07 卤0.67)ng/L and 824.72 卤141.54 ng / L before and after treatment, respectively. There was a positive correlation between IL-17IL-23 and PASI score before and after treatment. Conclusion: Tripterygium wilfordii polyglycoside is effective in the treatment of psoriasis vulgaris and may play an important role by regulating the level of IL-6 IL-17 and IL-23 in serum of Th17 cells.
【作者单位】：慈溪市皮肤病医院皮肤科;
【分类号】：R758.63

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