HIF-1α、MMP-2在皮肤鳞癌中的表达

发布时间：2018-05-20 17:21

本文选题：鳞状细胞癌 + HIF-1α　；参考：《青岛大学》2012年硕士论文

【摘要】：目的研究缺氧诱导因子-1α(HIF-1α)、基质金属蛋白酶-2(MMP-2)在皮肤鳞癌中的表达及相关性。方法应用免疫组化法检测42例皮肤鳞癌、13例BOWEN病、11例正常皮肤组织中HIF-1α、MMP-2的表达。结果HIF-1α和MMP-2在正常皮肤组织、BOWEN病及皮肤鳞癌中的表达率为O%、61.54%、73.81%及0%、38.46%、50%,其差异有统计学意义(X2=23.675, P0.05;X2=12.955, P0.05).HIF-1α、MMP-2在皮肤鳞癌中的表达高于正常皮肤组织,差异有统计学意义(X2=16.638, P0.05; X2=7.139, P0.05).HIF-1α、 MMP-2在Bowen病中的表达高于正常皮肤组织,差异有统计学意义(P=0.02；P=0.041)。在皮肤鳞癌中HIF-1α与MMP-2的表达呈正相关性(rs=0.379,P0.05)。结论HIF-1α、MMP-2在皮肤鳞癌中高度表达,两者在皮肤鳞癌中的表达具有密切相关性。
[Abstract]:Objective to study the expression and correlation of hypoxia inducible factor-1 伪 (HIF-1 伪) and matrix metalloproteinase-2 (MMP-2) in cutaneous squamous cell carcinoma (SCC). Methods Immunohistochemical method was used to detect the expression of HIF-1 伪 -MMP-2 in 13 cases of BOWEN's disease and 11 cases of normal skin tissue. Results the expression rates of HIF-1 伪 and MMP-2 in normal skin tissues were 61.54%, 73.81% and 38.4650%, respectively. The difference was statistically significant (P 0.05). The expression of P0.05).HIF-1 伪 MMP-2 in cutaneous squamous cell carcinoma was significantly higher than that in normal skin tissues, and the expression of P0.05).HIF-1 伪 MMP-2 in skin squamous cell carcinoma was significantly higher than that in normal skin tissues. The difference was statistically significant (P 0.05, P 0.05), and the expression of P0.05).HIF-1 伪 and MMP-2 in Bowen's disease was higher than that in normal skin tissue, and the difference was statistically significant (P < 0.05). There was a positive correlation between the expression of HIF-1 伪 and MMP-2 in cutaneous squamous cell carcinoma. Conclusion HIF-1 伪 -MMP-2 is highly expressed in cutaneous squamous cell carcinoma, and there is a close correlation between the expression of MMP-2 and HIF-1 伪 in cutaneous squamous cell carcinoma.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.5

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