慢性特发性荨麻疹患者血清血管活性肠肽、白介素-5和组胺的测定及意义

发布时间：2018-05-21 19:38

本文选题：慢性特发性荨麻疹 + 血管活性肠肽　；参考：《青岛大学》2011年硕士论文

【摘要】：目的测定血管活性肠肽(VIP)、白介素(IL)-5和组胺在慢性特发性荨麻疹(CIU)患者血清中的水平,并与正常对照组进行比较,初步探讨神经精神因素在CIU发病中的作用。方法随机收集(2008年11月-2009年4月)在我院门诊确诊的CIU患者46例,随机选择健康志愿者34例,应用ELISA法测定46例CIU患者及34例正常人血清VIP、IL-5和组胺的含量,采用SPSS17.0统计软件包进行统计学处理,CIU组和对照组血清VIP、IL-5、组胺水平统计推断采用t检验,CIU组血清VIP、IL-5、组胺水平之间相关分析采用直线相关分析。检验水准α=0.05。结果CIU组血清VIP、IL-5和组胺水平均高于正常对照组(P0.05)。CIU组血清VIP与组胺水平成正相关(r=0.343,P0.05),血清VIP与IL-5(r=-0.040,P0.05)以及IL-5与组胺之间(r=-0.057,P0.05)无相关性。结论本研究结果进一步证实组胺在CIU发病中的关键性作用,并且提示VIP可能通过组胺释放而诱发或加重CIU,推测神经精神因素在CIU发病中的机理之一可能是通VIP触发肥大细胞脱颗粒释放组胺诱发或加重CIU。一方面,神经精神因素可能通过此途径诱发CIU而另一方面,CIU又会加重患者的心理负担,刺激VIP的进一步释放,从而进一步加重病情,形成恶性循环,这可能是CIU慢性反复发作的原因之一。本研究提示CIU患者可能存在Th2亢进,但在CIU发病机制中,VIP是否通过影响Thl/Th2亚群失衡而发挥作用,尚需深入研究。
[Abstract]:Objective to determine the level of vasoactive intestinal peptide (VIP), interleukin (IL) -5 and histamine in the serum of patients with chronic idiopathic urticaria (CIU), and to compare with the normal control group and preliminarily explore the role of neuropsychic factors in the pathogenesis of CIU. Methods 46 patients with CIU in our hospital were randomly collected (November 2008 -2009 year April) and were randomly selected. 34 healthy volunteers were selected. The serum levels of VIP, IL-5 and histamine in 46 cases of CIU and 34 normal subjects were measured by ELISA. The serum VIP, IL-5 and histamine levels in the CIU group and the control group were determined by t test, VIP in the CIU group, IL-5, and histamine levels in the CIU group and the control group. The correlation analysis between the levels of histamine and the histamine was linear correlation. The level of serum VIP, IL-5 and histamine in group CIU was higher than that of the normal control group (P0.05).CIU group (r=0.343, P0.05), and there was no correlation between the serum VIP and IL-5 (r=-0.040, =0.05.) and histamine. Conclusion the results of this study further confirmed that histamine is in the pathogenesis. The key role in the study suggests that VIP may induce or aggravate CIU through histamine release, presumably one of the mechanisms of neuropsychic factors in the pathogenesis of CIU may be through VIP triggering mast cells degranulation and releasing histamine to induce or aggravate CIU.. Neuropsychic factors may pass through this pathway to induce CIU and on the other, CIU will aggravate. The psychological burden of patients, stimulating the further release of VIP, further aggravating the condition and forming a vicious cycle, may be one of the reasons for the chronic recurrent attacks of CIU. This study suggests that CIU patients may have Th2 hyperactivity, but in the pathogenesis of CIU, whether VIP plays a role in the imbalance of the Thl/ Th2 subgroup is still needed to be studied in depth.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.24

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