轻中度痤疮患者面部皮肤生理指标分析研究

发布时间：2018-05-23 18:36

本文选题：痤疮 + 皮脂　；参考：《安徽医科大学学报》2017年12期

【摘要】：目的通过对轻中度痤疮患者与正常人面部各生理指标的测定比较,分析其中的差异,探讨皮肤生理指标的异常与痤疮发生发展的相关性,为今后对痤疮的预防、控制及治疗提供理论基础。方法选取114例受试对象,实验组为痤疮患者57例,对照组为正常健康志愿者57例。运用无创性皮肤生理功能检测仪,测量受试者前额、鼻部和脸颊的角质层含水量、经表皮失水量(TEWL)、皮肤油脂、皮肤表面p H值、皮肤黑色素、皮肤血红素以及皮肤弹性。另外,对受试者的眼角只做弹性测量。统计分析痤疮患者与正常人各部位各项指标的差异。结果实验组前额、脸颊的角质层含水量低于对照组,差异有统计学意义(P0.05);实验组前额、脸颊的TEWL值高于对照组,差异有统计学意义(P0.05);实验组前额、鼻部、脸颊的皮肤油脂和血红素含量高于对照组,差异有统计学意义(P0.05)。另外,实验组前额、鼻部、脸颊的p H值、黑色素含量、弹性值,鼻部的角质层含水量和TEWL值,以及眼角的弹性值与对照组相比,均差异无统计学意义。结论痤疮患者与正常人相比,面部皮肤屏障功能出现损伤,皮脂分泌增多,TEWL和血红素含量升高,角质层含水量降低与痤疮的发生发展存在相关性。
[Abstract]:Objective to study the relationship between the abnormal skin physiological indexes and the occurrence and development of acne in order to prevent acne in the future by comparing the physiological indexes of the patients with mild and moderate acne and the normal people, and to analyze the differences between the physiological indexes of the skin and the occurrence and development of acne. Control and treatment provide theoretical basis. Methods 114 subjects were selected, 57 acne patients in experimental group and 57 healthy volunteers in control group. Non-invasive skin physiological function tester was used to measure the water content in the cuticle of forehead, nose and cheek, the amount of water loss through the epidermis, the skin grease, the pH value of the skin surface, the melanin, heme and elasticity of the skin. In addition, only elastic measurements were made of the eye corners of the subjects. Statistical analysis of acne patients and normal people in the various parts of the differences. Results the water content of the cuticle of the forehead and cheek of the experimental group was lower than that of the control group, the difference was statistically significant (P 0.05), the TEWL value of the forehead and cheek of the experimental group was higher than that of the control group, and the difference was statistically significant (P 0.05). The contents of skin oil and heme in the cheek were higher than those in the control group, and the difference was statistically significant (P 0.05). In addition, there was no significant difference in pH value, melanin content, elasticity value, water content and TEWL value of cuticle and the elasticity of eye corner between the experimental group and the control group. Conclusion compared with normal people, the facial skin barrier function is damaged, sebum secretion is increased and the content of TEWL and heme in acne patients is increased. The decrease of water content in keratinocytes is related to the occurrence and development of acne.
【作者单位】：安徽医科大学第一附属医院皮肤性病科;安徽医科大学皮肤病研究所;
【基金】：国家自然科学基金(编号:81361128014)
【分类号】：R758.733

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