人乳头状瘤病毒感染和复发性尖锐湿疣与细胞免疫水平的关系研究

发布时间：2018-05-25 04:22

本文选题：人乳头状瘤病毒 + 复发　；参考：《中华医院感染学杂志》2017年11期

【摘要】：目的探讨人乳头状瘤病毒(HPV)感染和复发性尖锐湿疣细胞皮肤免疫水平的关系,为临床预防尖锐湿疣复发提供理论依据。方法选取2015年1月-2016年6月在医院性病科门诊治疗的尖锐湿疣患者136例,分为复发组85例和未复发组51例,比较两组患者不同HPV感染亚型分布以及HPV基因型,比较两组患者外周T淋巴细胞亚群分布的差异。结果复发组患者高危型HPV分布率为69.4%显著高于未复发组31.4%,未复发组患者低危型HPV分布率为68.6%显著高于复发组30.6%,差异有统计学意义(P0.05);复发组与未复发组患者HPV感染均以低危型HPV6,HPV11以及HPV43为主,未复发组检测到高危型基因较少,复发组患者检测到高危型基因较多;复发组患者CD3+含量(66.8±7.5%),CD_4~+含量(32.8±5.3%),CD_4~+/CD_8~+比值(0.8±0.1)均显著低于未复发组CD3+含量(75.4±8.3%),CD_4~+含量(39.2±4.8%),CD_4~+/CD_8~+比值(1.2±0.2),复发组患者CD_8~+含量(40.3±4.8%)显著高于未复发组(32.5±5.2%),差异有统计学意义(P0.05);治疗3个月后,复发组患者CD3+(64.8±6.1%),CD_4~+含量(31.5±5.4%),CD_4~+/CD_8~+比值(0.8±0.1)均显著低于未复发组患者CD3+(75.7±8.5%),CD_4~+含量(38.1±4.6%),CD_4~+/CD_8~+比值(1.1±0.2),复发组患者CD_8~+含量(41.6±4.5%)显著高于未复发组(33.7±5.5%),差异有统计学意义(P0.05)。结论尖锐湿疣患者HPV感染的亚基因型和患者治疗后复发存在密切的联系,尖锐湿疣患者在接受治疗前的细胞免疫水平与疾病复发之间存在密切联系,为临床预防尖锐湿疣的复发以及有效治疗尖锐湿疣的复发提供科学依据。
[Abstract]:Objective to investigate the relationship between human papillomavirus (HPV) infection and skin immune level of recurrent condyloma acuminatum cells, and to provide theoretical basis for clinical prevention of recurrence of condyloma acuminatum. Methods from January 2015 to June 2016, 136 patients with condyloma acuminatum were divided into recurrent group (n = 85) and non-recurrent group (n = 51). The distribution of different HPV infection subtypes and HPV genotype were compared between the two groups. To compare the distribution of peripheral T lymphocyte subsets between the two groups. Results the distribution rate of high risk HPV in recurrent group was 69.4% higher than that in non-recurrence group 31.44.The distribution rate of low-risk HPV in non-recurrence group was 68.6%, which was significantly higher than that in recurrent group (30.6%), the difference was significant (P 0.05), and the HPV infection in recurrent group and non-recurrence group was significantly higher than that in non-recurrence group (P < 0.05). Low risk type HPV6, HPV11 and HPV43 were the main types. High risk genes were detected less in non-recurrence group and more in relapse group. The CD3 content in patients with recurrence was significantly lower than that in patients without recurrence (66.8 卤7.5and 32.8 卤5.3) and the ratio of CD4- / -CD8- (0.8 卤0.1) was significantly lower than that in patients without recurrence (75.4 卤8.3C), and the ratio of CD4-% CD8- (8-) was 1.2 卤0.2in patients with recurrence, and 40.3 卤4.8in patients with recurrence, which was significantly higher than that in patients without recurrence (32.5 卤5.2cm), and the difference was significant after 3 months of treatment, the difference was significant (P 0.05). The CD4 ~ content of CD3 in the patients with recurrence (64.8 卤6.1) was significantly lower than that in the patients without recurrence (31.5 卤5.4) and the ratio of CD4- / CD8- (0.8 卤0.1) was significantly lower than that in the patients without recurrence (75.7 卤8.5). The ratio of CD4- / -CD8 ~ + in patients with recurrence was significantly higher than that in the patients without recurrence (P 0.05). There was a significant difference between the patients with recurrence and those without recurrence (P 0.05). Conclusion the subgenotype of HPV infection in condyloma acuminatum patients is closely related to the recurrence after treatment, and the cellular immunity level of condyloma acuminatum patients before treatment is closely related to the recurrence of the disease. To prevent the recurrence of condyloma acuminatum and to effectively treat the recurrence of condyloma acuminatum.
【作者单位】：广东省人民医院广东省医学科学院皮肤科;
【基金】：广东省医学科学技术研究基金资助项目(A2015148)
【分类号】：R752.53

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