维生素D及其受体对毛囊生长周期调控的研究进展

发布时间：2018-05-26 21:22

本文选题：维生素D受体 + 维生素D　；参考：《临床皮肤科杂志》2014年10期

【摘要】：毛囊是体表不断自我循环的组织器官,形成于胚胎期,出生后逐渐成熟。由角质形成细胞和真皮乳头细胞组成,维生素D受体(VDR)是维持角质形成细胞正常功能的重要组成成分,开启毛囊生长周期。VDR的DNA结合区和活性功能2区在毛囊生长周期中起作用。VDR的经典转录途径是结合配体1α,25二羟维生素D_3(VD_3),与二聚化搭档维A酸X受体a(RXRa)形成异质二聚体,吸引共激活剂或者共抑制剂,作用于含有VDR反应元件启动子的基因,调节转录。VDR调节毛囊生长周期不需要VD_3,但VD_3及类似物对毛囊确有一定的作用。VDR的共抑制剂无毛基因、共激活剂MED1及二聚化配体RXRa受损都会导致毛发脱落。毛囊生理主要涉及Wnt信号通路和Shh信号通路,两条通路之间可相互作用,VDR以非经典途径调节这两条信号通路。维生素D的研究较少,VDR的具体作用机制待进一步研究。
[Abstract]:Hair follicles are tissues and organs which are constantly circulating on the body surface. They are formed in embryonic stage and mature gradually after birth. Vitamin D receptor (VDR) is an important component to maintain the normal function of keratinocytes, which consists of keratinocytes and dermal papilla cells. The classic transcriptional pathway of DNA binding region and active functional region 2 that open the growth cycle of hair follicle. The classical transcriptional pathway of VDR is to bind to ligand 1 伪 -25 dihydroxyvitamin D, and form a heterogeneous dimer with dimeric partner retinoic acid X receptor ahrxRa. In order to attract co-activator or co-inhibitor and act on genes containing promoter of VDR response element, VD3 is not required to regulate the growth cycle of hair follicles by transcription.VDR, but VD_3 and its analogues do have some effect on hair follicles. Loss of co-activator MED1 and dimer ligand RXRa can lead to hair loss. Hair follicle physiology mainly involves Wnt signaling pathway and Shh signal pathway, and the two pathways can interact with each other and regulate these two signaling pathways in a non-classical way. The specific mechanism of vitamin D in VDR needs to be further studied.
【作者单位】：南京医科大学第一附属医院皮肤性病科;
【分类号】：R758.71

【参考文献】