长春地区生殖器疱疹患者HSV血清型检测与流行病学特点

发布时间：2018-05-27 13:14

  本文选题：生殖器疱疹 + 特异性抗体检测(HSV　； 参考：《吉林大学》2011年硕士论文

【摘要】：目的了解长春地区生殖器疱疹患者中HSV-1和HSV-2的感染情况,并进行生殖器疱疹的流行病学特点分析。 方法采用酶联免疫吸附试验(ELISA)法对皮肤性病科门诊患者进行了HSV-1和HSV-2型血清抗体的检测,对其中530例临床诊断为生殖器疱疹患者,做了详细记录。 结果530例患者中男性311人(58.68%),女性219人(41.32%)。其中HSV-1 IgM抗体阳性的有60例(11.32%),HSV-1 IgG抗体阳性的有471例(88.87%),HSV-2 IgM抗体阳性的有213例(40.19%),HSV-2 IgG抗体阳性的有349例(65.85%)。年龄中最小的为21天,最大的为88岁,以31~40岁最多为210例(39.62%),其次由多到少依次为21~30岁,41~50岁,51~60岁, 20岁以下,61岁以上。职业中主要以自由职业和民工最多,分别有89例和82例。非婚性性行为传播感染所致374例(70.57%)最多,配偶间传播为103例(19.43%),间接或母婴传播53例(10.00%)。外生殖器现在无皮损者有167人,占31.51%,生殖器或肛门周围有水疱、溃疡、糜烂,并排除硬下疳、软下疳和Behcet综合症等引起生殖器溃疡的疾病的患者有363人,占68.49%。初发的有304例(55.85%),复发的有226例(44.15%),其中频繁发作(≥6次/年)85人(16.04%)。 结论长春地区生殖器疱疹患者以HSV-2感染为主。女性近期感染患者多于男性。生殖器疱疹患者以21~40岁性活跃人群为高发年龄组,复发患者职业主要为自由职业和民工,以通过非婚性性行为途径感染为主。HSV-1IgM、HSV-2IgM抗体阳性率在初发患者中比例最高,非频繁复发患者主要以HSV-2 IgG阳性为主。
[Abstract]:Objective to investigate the infection of HSV-1 and HSV-2 in genital herpes patients in Changchun area and to analyze the epidemiological characteristics of genital herpes. Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect serum HSV-1 and HSV-2 antibodies in outpatients with cutaneous venereal diseases. Among them, 530 patients with genital herpes were recorded in detail. Results among 530 patients, 311 were male and 219 were female. Among them, there were 60 cases with HSV-1 IgM antibody positive and 471 cases with HSV-1 IgG antibody positive. There were 213 cases with HSV-2 IgM antibody positive, and there were 349 cases with HSV-2 IgG antibody positive. The youngest age was 21 days and the largest was 88 years old. Among them, 210 cases were 39.62 years old at the age of 31 ~ 40, followed by 21 ~ 30 years old, 41 ~ 1 ~ 50 years old and 51 ~ 60 years old, and under 20 years old or over 61 years old. Freelance and migrant workers were the most common occupations, 89 and 82, respectively. Among the 374 cases caused by non-marital sexually transmitted infections (70.57), there were 103 cases of spousal transmission, and 53 cases of indirect or mother-to-child transmission (10.00%). There are 167 people without skin lesions in the external genitals, accounting for 31.51.The patients with vesicles, ulcers, erosions around the genitals or anus, and excluding hard chancre, chancre and Behcet syndrome, have 363 patients, accounting for 68.49% of the diseases that cause genital ulcers. There were 304 cases with 55.85 cases with initial onset and 226 cases with 44.15 cases with recurrence, of which there were frequent episodes (鈮，

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