50岁以上带状疱疹患者后遗神经痛的影响因素及其防治

发布时间：2018-06-01 06:38

本文选题：带状疱疹 + 带状疱疹后遗神经痛　；参考：《中国皮肤性病学杂志》2014年12期

【摘要】：目的探讨50岁以上带状疱疹患者带状疱疹后遗神经痛(PHN)的影响因素及防治。方法收集本科2012年11月-2013年5月共88例50岁以上住院带状疱疹患者详细信息,定义PHN为疱疹消退后疼痛持续3个月以上。将年龄、性别、初发部位、皮损面积、疼痛程度、初期抗病毒治疗时间及疗程、是否合用小剂量糖皮质激素等列为自变量,建立Logistic回归模型,利用向前逐步法筛选出有统计学意义的变量。结果 Logistic回归分析结果显示:年龄(P=0.003,B=2.096)、起病时疼痛程度(P=0.010,B=2.011)及合并症(P=0.041,B=1.643)为PHN的危险因素;抗病毒治疗(P=0.043,B=-2.423)、营养神经及止痛治疗(P=0.032,B=-2.279)和合用小剂量糖皮质激素(P=0.054,B=-2.196)为保护因素。结论对50岁以上带状疱疹患者,尤其是初期疼痛剧烈或伴有其他内科疾病者应早期接受抗病毒、营养神经及止痛治疗,如无禁忌合用小剂量糖皮质激素可减少PHN的发生。
[Abstract]:Objective to investigate the influencing factors and prevention and treatment of postherpetic neuralgia (PHN) in patients over 50 years old with herpes zoster. Methods from November 2012 to May 2013 88 hospitalized patients over 50 years old with herpes zoster were collected and PHN was defined as pain lasting more than 3 months after herpes subsided. Age, sex, initial site, area of skin lesion, degree of pain, time and course of initial antiviral therapy, combination of low dose glucocorticoid and so on were taken as independent variables to establish Logistic regression model. The variables with statistical significance were screened by the method of forward step by step. Results the results of Logistic regression analysis showed that the risk factors of PHN were age group (P < 0.003), pain degree (P < 0.010) and concomitant disease (P < 0.041 / B ~ (1.643), and antiviral therapy (P ~ (0.043) B ~ (-2.423), nutritional nerve and analgesic therapy (P ~ (0.032) B ~ (-2.279) and low dose glucocorticoid P0.05B ~ (-2.196) were protective factors. Conclusion patients over 50 years old with herpes zoster, especially those with severe initial pain or other medical diseases, should be treated with antivirus, nutritional nerve and pain relief early, such as no contraindication and low dose glucocorticoid can reduce the incidence of PHN.
【作者单位】：郑州大学第一附属医院皮肤科;
【基金】：郑州大学研究生科学研究项目
【分类号】：R752.12

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