76例尖锐湿疣临床疗效研究

发布时间：2018-06-05 13:32

本文选题：尖锐湿疣 + 电离子　；参考：《大连医科大学》2011年硕士论文

【摘要】：目的:观察比较三种治疗尖锐湿疣方法的疗效并探讨联合治疗尖锐湿疣临床疗效。方法:回顾收集2008年12月~2010年11月就诊于大连医科大学附属二院皮肤科门诊,并已确诊为尖锐湿疣的患者76例,患者年龄在18-55岁之间,将76例的尖锐湿疣患者随机分为3组:A组20例、B组21例、C组35例。A、B、C三组患者在年龄、性别、皮损数目、大小、病程上的差异无显著性(P0.05),具有可比性。治疗前详细了解患者基本病情和发病相关情况,在治疗和观察中,由同一位观察者进行治疗及记录皮损的愈合情况。A组单纯多功能电离子治疗机治疗;B组多功能电离子治疗机治疗,外涂干扰素α-2b凝胶于患处,3次/d,连用8周;C组在B组基础上肌注干扰素α-2b注射液100万IU,每周3次,4周为一疗程,连用2个疗程,共8周。B、C组外用干扰素凝胶次数和方法均相同。6个月后观察三组患者治疗前后皮损变化并记录其不良反应。比较三组治疗效果及尖锐湿疣复发率。并对结果采用SPSS17.0统计学软件进行统计学数据处理,所得到的数据为计数资料,并使用卡方检验,取用P值0.05,差异有统计学意义。结果:三组治愈率分别为35.0%、71.4%及94.3% ,复发率分别为65%、28.6%及5.7%。A组单纯使用电离子治疗尖锐湿疣,复发率最高。B组电离子加外用干扰素α-2b凝胶治疗,复发率较单纯电离子治疗明显降低。C组电离子、外用干扰素α-2b凝胶加用肌注干扰素α-2b注射液三联疗法复发率最低。AB两组间的治愈率比较,单纯使用电离子治疗尖锐湿疣,治愈率低于电离子加外用干扰素α-2b凝胶治疗。X~2= 4.10 P=0.04 ,P0.05,AB两组间的治愈率的差异具有统计学意义。AC两组间的治愈率比较,单纯使用电离子治疗尖锐湿疣,治愈率同样低于电离子加外用干扰素α-2b凝胶治疗加肌注干扰素α-2b注射液三联疗法的C组,X~2= 19.66 P=0.01,P0.05。AC两组间的治愈率的差异具有统计学意义。BC两组间的治愈率比较,C组电离子、外用干扰素α-2b凝胶加肌注干扰素α-2b注射液三联疗法治愈率高于电离子加外用干扰素α-2b凝胶治疗。X~2= 3.88 P=0.04 ,P0.05,BC两组间的治愈率的差异具有统计学意义。三组的治愈率由高到低为CBA, X~2= 23.23,P=0.01 ,P0.05,ABC三组间的治愈率差异具有统计学意义,C组的治愈率最高。电离子治疗后,肌注干扰素α-2b注射液联合外用干扰素α-2b凝胶三联治疗方法,在治疗尖锐湿疣对比电离子联合外用干扰素α-2b凝胶和对比单纯电离子治疗均有明显的高治愈率和低复发率,该差异均有显著统计学意义。结论:多功能电离子联合干扰素凝胶外用、干扰素α-2b注射液肌注三联治疗方法治疗尖锐湿疣复发率低。在尖锐湿疣治疗中疗效确切,可显著提高治愈率和减少尖锐湿疣复发率,与此同时其经济实用、操作简便,值得临床推广。
[Abstract]:Objective: to observe and compare the efficacy of three methods in treating condyloma acuminatum and to explore the clinical effect of combined treatment of condyloma acuminatum. Methods: from December 2008 to November 2010, 76 patients with condyloma acuminatum, aged 18-55 years, who were admitted to the Department of Dermatology, second affiliated Hospital, Dalian Medical University, were retrospectively collected. 76 cases of condyloma acuminatum were randomly divided into 3 groups: group A (n = 20), group B (n = 21) and group C (n = 35). Prior to treatment, we understood in detail the basic condition of the patient and the related situation of the disease, and in the course of treatment and observation, The healing of skin lesions was recorded by the same observer. Group A was treated with simple multifunctional electric ion therapy machine and group B was treated with multifunctional electric ion therapy machine. Interferon 伪 -2b gel was applied to the affected area for three times a day for 8 weeks. Group C was intramuscularly injected with interferon 伪 -2b injection 1 million IUU on the basis of group B for 8 weeks, three times a week for 4 weeks as a course of treatment, and two consecutive courses of treatment. The times and methods of interferon gel were the same in group C for 8 weeks. After 6 months, the changes of skin lesions were observed and the adverse reactions were recorded. The curative effect and recurrence rate of condyloma acuminatum were compared among the three groups. The statistical data were processed by SPSS17.0 software. The data obtained were counted data, and the P value was 0.05 by chi-square test. The difference was statistically significant. Results: the cure rates of the three groups were 35.0% and 94.3%, respectively. The recurrence rates were 6528.6% and 5.7.A, respectively. The electric ions were used to treat condyloma acuminatum. The recurrence rate was the highest in group B and treated with interferon 伪 -2b gel. The recurrence rate of group C was significantly lower than that of group C. the relapse rate of group A was the lowest in combination of interferon 伪 -2b gel and intramuscular injection of interferon 伪 -2b injection. The cure rate of group A was lower than that of group B, and only electric ion was used to treat condyloma acuminatum. The cure rate was lower than that of electric ion plus interferon 伪 -2b gel. Xn2 = 4.10 P0. 04 and P0. 05% AB. The difference of cure rate between the two groups was statistically significant. The cure rate of AC group was higher than that of the other two groups, and only electric ion was used to treat condyloma acuminatum. The cure rate of group C was lower than that of group C treated by electroion plus interferon 伪 -2b gel plus intramuscular injection of interferon 伪 -2b injection. The difference of cure rate between group C and group C was statistically significant. The cure rate of group BC was higher than that of group C. The cure rate of interferon 伪 -2b gel combined with intramuscular interferon 伪 -2b injection was higher than that of electric ion plus interferon 伪 -2b gel. The cure rate of the three groups was from high to low to CBA. The difference of cure rate among the three groups was statistically significant. The cure rate of group C was the highest. After electroion therapy, interferon 伪 -2b injection was injected intramuscularly in combination with interferon 伪 -2b gel. In the treatment of condyloma acuminatum, electric ion combined with interferon 伪 -2b gel and electric ion therapy alone had obvious high cure rate and low recurrence rate, and the difference was statistically significant. Conclusion: multifunctional electroion combined with interferon gel is effective in the treatment of condyloma acuminatum. It is effective in the treatment of condyloma acuminatum. It can significantly improve the cure rate and reduce the recurrence rate of condyloma acuminatum. At the same time, it is economical and practical, simple to operate, and worthy of clinical popularization.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R752.53

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