脱细胞生物羊膜对甲床手术创面恢复的作用

发布时间：2018-06-06 23:39

本文选题：甲外科 + 羊膜　；参考：《四川大学学报(医学版)》2016年04期

【摘要】：目的明确脱细胞生物羊膜应用于甲床二期愈合的甲外科手术中,是否有促进创面愈合的作用。方法将行甲床手术后创面二期愈合的患者随机分配到治疗组(n=19)和对照组(n=19),甲床手术后第1天换药时,治疗组使用羊膜后覆盖凡士林纱布;对照组仅覆盖凡士林纱布。记录换药后1h、4h、8h、12h、24h、36h、48h、72h患者疼痛评分;记录创面愈合时间、甲生长时间、患者和医生对外观的满意度。结果两组患者基线一致,从换药后4h开始至换药后48h,两组疼痛评分差异有统计学意义(P0.05)。换药后24h治疗组全部患者疼痛消失。创面愈合时间:对照组平均需要(17.68±2.86)d,治疗组则需要(12.37±2.48)d,两者差异有统计学意义(P0.05)。甲床手术后第1天到甲完全生长所需时间:对照组平均需要(15.63±2.00)周,治疗组则需要(13.95±1.72)周,两者差异有统计学意义(P=0.016)。甲完全生长后,甲单位外观满意度评分:对照组(7.58±1.18)分,治疗组(7.61±1.38)分,两组间差异无统计学意义(P=0.919)。结论脱细胞生物羊膜可以促进甲床手术创面愈合。
[Abstract]:Objective to determine whether acellular amniotic membrane can promote wound healing in nail bed secondary healing. Methods patients with secondary wound healing after nail bed operation were randomly assigned to the treatment group and the control group. The treatment group was treated with vaseline gauze on the first day after nail bed operation, and the control group was only covered with vaseline gauze. The pain scores were recorded at 1 hour, 4 h, 8 h, 12 h, 24 h, 36 h, 48 h and 72 h after dressing change, and the wound healing time, nail growth time, satisfaction with appearance of the patients and doctors were recorded. Results the baseline of the two groups was the same, from 4 hours after the change of medicine to 48 hours after the change of medicine, the difference of pain score between the two groups was statistically significant (P 0.05). Pain disappeared in all patients in the treatment group 24 hours after dressing change. Wound healing time: the average time of wound healing was 17.68 卤2.86 days in the control group and 12.37 卤2.48 days in the treatment group. The difference between the two groups was statistically significant (P 0.05). The time from the first day to the complete growth of the nail bed: the control group needed 15.63 卤2.00 weeks on average, while the treatment group needed 13.95 卤1.72 weeks. The difference between the two groups was statistically significant. After the complete growth of A, the score of satisfaction with appearance of unit A was 7.58 卤1.18 in the control group and 7.61 卤1.38 in the treatment group. The difference between the two groups was not statistically significant (P < 0. 919). Conclusion acellular amniotic membrane can promote wound healing in nail bed operation.
【作者单位】：四川大学华西医院皮肤科;四川大学学报(医学版)编辑部;
【基金】：国家自然科学基金(No.81502747)资助
【分类号】：R751.05

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