环状肉芽肿81例临床及组织病理分析

发布时间：2018-06-07 09:33

本文选题：环状肉芽肿 + 临床表现　；参考：《中国皮肤性病学杂志》2017年08期

【摘要】：目的了解局限型和泛发型环状肉芽肿临床特点、组织学改变及治疗转归情况。方法回顾性分析2010年1月-2016年12月本科收治的81例皮肤环状肉芽肿患者临床资料。结果局限型环状肉芽肿41例,泛发型环状肉芽肿38例(泛发环形21例,播散丘疹型14例,非典型泛发型3例),皮下型1例,穿通型1例。组织病理改变以栅状肉芽肿多见(占69.14%),散在性组织细胞浸润仅占29.63%,上皮样结节型占1.23%。局限型以避光、局部外用糖皮质激素、冷冻等局部治疗为主,泛发型以系统性治疗为主,如糖皮质激素、复方甘草酸苷片、米诺环素、烟酰胺、雷公藤多苷片、羟氯喹、甲氨蝶呤、维甲酸类和窄谱中波紫外线(NB-UVB)照射均可取得满意疗效,但部分患者停药后皮损易复发。结论泛发型环状肉芽肿成人多发,组织病理学改变以栅状肉芽肿最为多见。局限型以局部治疗为主,泛发型以系统治疗为主。
[Abstract]:Objective to investigate the clinical features, histological changes and therapeutic outcome of localized and generalized annular granuloma. Methods the clinical data of 81 patients with cutaneous annular granuloma from January 2010 to December 2016 were retrospectively analyzed. Results there were 41 cases of localized ring granuloma, 38 cases of generalized ring granuloma (21 cases of generalized ring, 14 cases of disseminated papules, 3 cases of atypical generalized granuloma, 1 case of subcutaneous type and 1 case of perforating type). Most of the histopathological changes were grid granuloma (69.14%), diffuse histiocytic infiltration (29.63%) and epithelioid nodular type (1.23%). The localized type is light avoidance, topical use of glucocorticoid, cryotherapy and so on, and the generalized type is mainly systemic therapy, such as glucocorticoid, compound glycyrrhizin tablets, minocycline, nicotinamide, tripterygium wilfordii polyglycoside tablets, hydroxychloroquine, etc. Methotrexate, retinoic acid and NB-UVB (narrow band ultraviolet B) irradiation all achieved satisfactory results, but some patients were prone to relapse after drug withdrawal. Conclusion Universal ring granuloma is more common in adults, and the most common histopathological changes are grid granuloma. The local treatment was the main type, and the systemic treatment was the most common type.
【作者单位】：河南省人民医院;
【分类号】：R758.6

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