角化棘皮瘤43例临床及病理分析

发布时间：2018-06-10 07:46

本文选题：角化棘皮瘤 + 临床表现　；参考：《中国皮肤性病学杂志》2017年04期

【摘要】：目的了解角化棘皮瘤患者的临床表现和组织病理特点。方法回顾性分析本科2012年1月-2016年8月经组织病理确诊的43例角化棘皮瘤患者的临床资料。结果 43例角化棘皮瘤患者中,男20例,女23例,均为单发皮损,50岁以上40例(占93.02%),平均发病年龄(70.72±13.59)岁。皮损好发于头、面及四肢远端等暴露部位。3例早期皮损,39例成熟期皮损,1例消退期皮损。呈"火山口状"溃疡33例(76.74%)、皮角3例(6.98%)、角化过度30例(69.77%)、角化不全24例(55.81%)、角囊肿26例(60.47%)、毛玻璃样细胞20例(46.51%)、异型细胞18例(41.86%)、病理性核分裂相10例(23.26%)及真皮炎性细胞浸润34例(79.07%)。均予手术切除皮损,至今未见复发。本病临床与病理诊断符合率53.49%,易被误诊为皮肤鳞状细胞癌、寻常疣等。结论角化棘皮瘤好发于中老年人群,单发性皮损手术治疗预后良好,皮损组织病理检查有助于鉴别诊断。
[Abstract]:Objective to investigate the clinical and histopathological features of keratoacanthoma. Methods the clinical data of 43 cases of keratoacanthoma diagnosed by histopathology from January 2012 to August 2016 were retrospectively analyzed. Results among 43 cases of keratoacanthoma, 20 cases were males and 23 cases were females. All of them were over 50 years old with single lesions (93.02%). The average age of onset was 70.72 卤13.59 years. The lesions occurred at the exposed sites of head, face and distal extremities in 39 cases of early stage, 39 cases of mature lesions and 1 case of receding lesions. There were 33 cases of "crater" ulcers, 3 cases of keratinocytes, 30 cases of hyperkeratosis, 24 cases of hypokeratosis, 26 cases of keratosis and 55.81D, 26 cases of keratocysts, 20 cases of hair glass-like cells, 46.51 cases of fibrous cells, 18 cases of dysplastic cells, 10 cases of pathological mitotic phase and 23.2626%), and 34 cases of dermal inflammatory cell infiltration. All skin lesions were surgically resected and no recurrence was seen so far. The coincidence rate of clinical diagnosis and pathological diagnosis was 53.49%, which was easily misdiagnosed as cutaneous squamous cell carcinoma, verruca vulgaris and so on. Conclusion keratoacanthoma is easy to occur in middle and old people, and the prognosis of single lesion is good. Histopathological examination of keratoacanthoma is helpful for differential diagnosis.
【作者单位】：南通大学第二附属医院皮肤科;
【分类号】：R739.5

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