肠道微生物与皮肤疾

发布时间：2018-06-17 15:15

本文选题：皮肤 + 肠道　；参考：《科学通报》2017年05期

【摘要】：皮肤疾病,特别是湿疹、皮炎和痤疮等不仅影响个人形象,还可引起躯体感觉不适或精神异常.皮肤疾病影响人群广泛,病因复杂,复发率高,全球范围内患病人数不断增加.皮肤疾病与心理疾病之间存在密切联系,并且心理疾病的患病比例增长趋势也很明显.近年来的研究表明,肠道状态、肠道微生物以及心理疾病与皮肤疾病的关联称作肠道-大脑-皮肤轴(肠-脑-皮轴).肠道微生物可影响皮肤疾病的发生,并且精神状态与肠道微生物健康状况可折射皮肤健康状况.反之,皮肤状况也可作为精神状态和肠道微生物健康状况的评估参照.饮食是通过肠-脑-皮轴影响皮肤的重要因素,而心理因素对皮肤健康的影响也不能忽视.通过将肠道和皮肤微生物、肠道状态、大脑以及皮肤作为一个系统,而非独立对待,进而围绕肠-脑-皮轴进行干预将是解决皮肤疾病的重要方法.未来皮肤病的治疗趋势是将饮食、益生菌、益生元、药物和心理健康等方式综合运用.本文将重点介绍人类第二基因组——人体微生物组、肠道-大脑-皮肤轴与皮肤疾病的关系以及相互影响有关的研究进展.
[Abstract]:Skin diseases, especially eczema, dermatitis and acne, not only affect personal image, but also cause somatic discomfort or mental disorders. Skin disease affects a wide range of people, complex etiology, high recurrence rate, the number of patients in the world is increasing. There is a close relationship between skin diseases and psychological diseases, and the increasing trend of the prevalence of psychological diseases is also obvious. Recent studies have shown that intestinal conditions, intestinal microbes, and the association of mental disorders with skin diseases are known as the entero-brain-skin axis. Intestinal microorganism can affect the occurrence of skin disease, and mental state and intestinal microorganism health state can reflect the skin health condition. Conversely, the skin condition can also be used as a reference for the assessment of mental state and intestinal microbial health. Diet is an important factor influencing skin through entero-brain-skin axis, and the influence of psychological factors on skin health can not be ignored. By treating intestinal and skin microbes, intestinal states, brain and skin as a system rather than independent treatment, and then intervening around the entero-brain-skin axis, it will be an important way to solve skin diseases. In the future, the treatment trend of skin diseases is to combine diet, probiotics, drugs and mental health. This paper will focus on the research progress of the relationship between the second human genome-human microorganism, the relationship between intestinal, cerebral-skin axis and skin diseases, and the interaction between them.
【作者单位】：中国科学院心理研究所心理健康重点实验室;
【基金】：中国博士后科学基金(2013M541072) 日本未来生命科学研究院资助
【分类号】：R751

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