膦甲酸钠治疗112例带状疱疹的疗效和安全性回顾性分析

发布时间：2018-06-19 19:34

本文选题：膦甲酸钠 + 带状疱疹　；参考：《中国皮肤性病学杂志》2014年12期

【摘要】：目的探讨膦甲酸钠氯化钠注射液治疗带状疱疹的疗效和安全性。方法回顾分析2007年1月-2013年1月在本科住院应用膦甲酸钠氯化钠注射液治疗带状疱疹的患者的病历资料,记录患者一般情况,症状体征和给药方式,以及疗效评价参数,包括:皮疹控制天数,皮疹大部好转天数,皮疹痊愈天数,疼痛开始缓解天数,疼痛大部消退天数,用药前和用药7d的疼痛程度视觉模拟评分(visual analogue scale,VAS)以及不良事件等。对数据进行统计学分析和分组比较。结果共采集病例205例,符合入组条件112例。疗效评价:平均皮疹控制天数2.3d,平均皮疹好转天数6.0d,平均皮疹痊愈天数10.6d。平均疼痛开始缓解天数2.8d,平均疼痛大部分消退天数8.7d。用药7d VAS平均改善56.53%,有效率93.14%。每日1次与2次给药组之间及男女性别组间疗效差异无统计学意义。低龄组疗效指标均优于高龄组。中低VAS组疗效指标均优于高VAS组。不良反应发生率3.57%,无严重不良反应。结论膦甲酸钠氯化钠注射液治疗带状疱疹有较好疗效,可以较快控制皮疹和改善疼痛症状。在优化给药方式前提下,膦甲酸钠氯化钠注射液治疗带状疱疹有较好的安全性。
[Abstract]:Objective to investigate the efficacy and safety of sodium phosphonate and sodium chloride injection in the treatment of herpes zoster. Methods the medical records of patients with herpes zoster treated with sodium phosphonate and sodium chloride injection from January 2007 to January 2013 were analyzed retrospectively. It included: the days of skin rash control, the days of most improvement of rash, the days of skin rash recovery, the days of beginning to relieve the pain, the days of most of the pain receding, the visual analogue scores of pain degree and visual analogue scale before and after 7 days of medication, and the adverse events and so on. The data were statistically analyzed and grouped. Results 205 cases were collected, 112 cases were in accordance with the condition of admission. The curative effect evaluation: the average rash control days were 2.3 days, the average rash improvement days were 6.0 days, the average rash cure days were 10.6 days. The average pain relief time was 2.8 days, and the average pain relief days were 8.7 days. The average improvement of VAS in 7 days was 56.53 and the effective rate was 93.14. There was no significant difference in curative effect between once and twice daily administration groups and between male and female groups. The curative effect of low age group was better than that of old age group. The curative effect of low and low VAS group was better than that of high VAS group. The incidence of adverse reactions was 3.57 and there was no serious adverse reaction. Conclusion Phosphoformate sodium chloride injection has a better effect on herpes zoster and can quickly control rash and improve pain symptoms. Under the premise of optimizing the administration mode, phosphonium sodium chloride injection has better safety in treating herpes zoster.
【作者单位】：北京大学第三医院皮肤科;
【分类号】：R752.12

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