自体血混合曲安奈德、IL-2、利多卡因联合斑秃丸治疗斑秃的疗效

发布时间：2018-06-22 22:53

本文选题：斑秃 + 自体血　；参考：《重庆医学》2016年13期

【摘要】：目的探讨自体血加曲安奈德、白细胞介素-2(IL-2)、利多卡因局部封闭注射联合斑秃丸治疗斑秃的疗效。方法治疗组62例采用自体血(2mL)加曲安奈德(第1~4周剂量递减,分别为25、20、15、10 mg)、IL-2(20万单位)、2%利多卡因(2mL)组成"混合液"皮损处局部封闭注射,每周1次,共4周;对照1组53例采用自体血(2mL)加IL-2(20万单位)、2%利多卡因(2mL)组成"混合液"皮损处局部封闭注射,每周1次,共4周;对照2组51例采用自体血(2mL)加2%利多卡因(2mL)组成"混合液"皮损处局部封闭注射,每周1次,共4周。3组患者均同时给予斑秃丸早、中、晚各20粒(10g)口服,以4周为1个疗程。结果治疗组痊愈率为54.84%,总有效率为93.55%,对照1组痊愈率为35.85%,总有效率为73.58%,对照2组痊愈率为27.45%,总有效率为54.90%。治疗组和对照1组痊愈率、总有效率比较差异有统计学意义(χ~2=4.417,P=0.042;χ~2=8.626,P=0.003);治疗组和对照2组痊愈率、总有效率比较,差异有统计学意义(χ~2=8.590,P=0.003;χ~2=22.98,P=0.000);对照1组和对照2组痊愈率比较,差异无统计学意义(χ~2=0.846,P=0.358),总有效率比较,差异有统计学意义(χ~2=3.958,P=0.047)。结论自体血加曲安奈德、IL-2、利多卡因局部封闭注射联合斑秃丸治疗斑秃疗效满意,无明显不良反应。
[Abstract]:Objective to investigate the effect of autologous blood plus triamcinolone acetonide, interleukin -2 (IL-2) and local closed injection of lidocaine combined with alopecia areata in the treatment of alopecia areata. 62 cases were treated by autologous blood (2mL) Gach Ann Ned (25,20,15,10 mg), IL-2 (200 thousand units), and 2% lidocaine (2mL), and 2% lidocaine (2mL). A closed injection was 1 times a week for 4 weeks, and 53 cases in the 1 groups were treated with autologous blood (2mL) plus IL-2 (200 thousand units) and 2% lidocaine (2mL) to form a "mixed solution" local closed injection, 1 times a week for 4 weeks, and 51 cases of the 2 groups used autologous blood (2mL) and 2% lidocaine (2mL) to form the local closed injection of "mixed liquid", 1 times a week, altogether 4 weeks.3 group. At the same time, the patients were given alopecia areata pills at the same time, 20 tablets (10g) were taken orally in the middle and late 4 weeks. The recovery rate of the treatment group was 54.84%, the total effective rate was 93.55%, the cure rate of the control 1 groups was 35.85%, the total effective rate was 73.58%, the recovery rate of the 2 group was 27.45%, the total effective rate was 54.90%. treatment group and the control group, the total effective rate was different. Statistical significance (x ~2=4.417, P=0.042; X ~2=8.626, P=0.003); the total effective rate of the 2 groups in the treatment group and the control group was statistically significant (x ~2=8.590, P=0.003; X ~2=22.98, P=0.000), and there was no statistical significance (x ~2=0.846, P=0.358) in the 2 groups of the control group and the control group (x ~2=0.846, P=0.358), and the total effective rate was compared, the difference was statistically significant ( (~2=3.958, P=0.047). Conclusion autologous blood plus triamcinolone acetonide, IL-2 and lidocaine injection combined with alopecia areata pill is effective in treating alopecia areata, with no obvious side effects.
【作者单位】：江苏省淮安市疾病控制中心;徐州医学院;
【分类号】：R758.71

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